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  1. The premature aging and cancer-prone Werner and Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN and BLM, respectively. Recently, both WRN and BLM (as well as several other RecQ members) ...

    Authors: Amrita Machwe, Enerlyn M Lozada, Liren Xiao and David K Orren

    Citation: BMC Molecular Biology 2006 7:1

    Content type: Research article

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  2. Pseudouridine (Ψ) is an abundant modified nucleoside in RNA and a number of studies have shown that the presence of Ψ affects RNA structure and function. The positions of Ψ in spliceosomal small nuclear RNAs (...

    Authors: Jeffrey R Patton and Richard W Padgett

    Citation: BMC Molecular Biology 2005 6:20

    Content type: Research article

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  3. The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well known, although knockout of the gene in Drosophila or e...

    Authors: Gulshan Sunavala-Dossabhoy, Sri Kripa Balakrishnan, Siddhartha Sen, Sam Nuthalapaty and Arrigo De Benedetti

    Citation: BMC Molecular Biology 2005 6:19

    Content type: Research article

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  4. In the retina, many of the genes that encode components of the visual transduction cascade and retinoid recycling are exclusively expressed in photoreceptor cells and show highly stereotyped temporal and spati...

    Authors: Deborah C Otteson, Hong Lai, Yuhui Liu and Donald J Zack

    Citation: BMC Molecular Biology 2005 6:15

    Content type: Research article

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  5. Trans- translation releases stalled ribosomes from truncated mRNAs and tags defective proteins for proteolytic degradation using transfer-messenger RNA (tmRNA). This small stable RNA represents a hybrid of tRNA- ...

    Authors: Jody Burks, Christian Zwieb, Florian Müller, Iwona Wower and Jacek Wower

    Citation: BMC Molecular Biology 2005 6:14

    Content type: Research article

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  6. Cdc23/Mcm10 is required for the initiation and elongation steps of DNA replication but its biochemical function is unclear. Here, we probe its function using a novel approach in fission yeast, involving Cdc23 ...

    Authors: Xiaowen Yang, Juraj Gregan, Karola Lindner, Hedi Young and Stephen E Kearsey

    Citation: BMC Molecular Biology 2005 6:13

    Content type: Research article

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  7. In humans, mutation of ELAC2 is associated with an increased risk of prostate cancer. ELAC2 has been shown to have tRNase Z activity and is associated with the γ-tubulin complex.

    Authors: Yang Chen, Audrey Beck, Christina Davenport, Yuan Chen, Donna Shattuck and Sean V Tavtigian

    Citation: BMC Molecular Biology 2005 6:12

    Content type: Research article

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  8. Preparation of RNA free from DNA is a critical step before performing RT-PCR assay. Total RNA isolated from several sources, including those obtained from Saccharomyces cerevisiae, using routine methodologies are...

    Authors: Eduardo M Del Aguila, Marcio B Dutra, Joab T Silva and Vânia MF Paschoalin

    Citation: BMC Molecular Biology 2005 6:9

    Content type: Research article

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  9. The promoter of the keratin 18 (K18) gene is 5- to 10-fold more active in tumorigenic (T-type) cell clones derived from the SW613-S human colon carcinoma cell line than in non-tumorigenic (NT-type) clones. We ...

    Authors: Cécile Delouis, Philippe Prochasson, Madeleine Laithier and Olivier Brison

    Citation: BMC Molecular Biology 2005 6:8

    Content type: Research article

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  10. The current investigation was undertaken to determine key steps differentiating G:T and G:A repair at the H-ras oncogenic hot spot within the nuclear environment because of the large difference in repair efficien...

    Authors: Michael Edelbrock, Huiling He, Allen Schroering, Martha Fernstrom, Sangeetha Bathala and Kandace J Williams

    Citation: BMC Molecular Biology 2005 6:6

    Content type: Research article

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  11. Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children. The interaction of T. vaginalis with ...

    Authors: Ashwini S Kucknoor, Vasanthakrishna Mundodi and JF Alderete

    Citation: BMC Molecular Biology 2005 6:5

    Content type: Research article

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  12. The parasitic protozoa belonging to Leishmania (L.) donovani complex possess abundant, developmentally regulated cathepsin L-like cysteine proteases. Previously, we have reported the isolation of cysteine proteas...

    Authors: Vasanthakrishna Mundodi, Ashwini S Kucknoor and Lashitew Gedamu

    Citation: BMC Molecular Biology 2005 6:3

    Content type: Research article

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  13. The enzyme glucose-6-phosphatase catalyzes the dephosphorylation of glucose-6-phosphatase to glucose, the final step in the gluconeogenic and glycogenolytic pathways. Expression of the glucose-6-phosphatase ge...

    Authors: Gerald Thiel, Jude Al Sarraj and Luisa Stefano

    Citation: BMC Molecular Biology 2005 6:2

    Content type: Research article

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  14. Coupling of alternative splicing with nonsense-mediated mRNA decay (NMD) may regulate gene expression. We report here the identification of a nonsense alternative transcript of the fumarylacetoacetate hydrolase (

    Authors: Natacha Dreumont, Antonella Maresca, Jean-François Boisclair-Lachance, Anne Bergeron and Robert M Tanguay

    Citation: BMC Molecular Biology 2005 6:1

    Content type: Research article

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  15. An Escherichia coli strain in which RecBCD has been genetically replaced by the bacteriophage λ Red system engages in efficient recombination between its chromosome and linear double-stranded DNA species sharing ...

    Authors: Anthony R Poteete, Anita C Fenton and Ashwini Nadkarni

    Citation: BMC Molecular Biology 2004 5:22

    Content type: Research article

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  16. DNA polymerases α and δ play essential roles in the replication of chromosomal DNA in eukaryotic cells. DNA polymerase α (Pol α)-primase is required to prime synthesis of the leading strand and each Okazaki fr...

    Authors: Fiona C Gray, J Richard G Pohler, Emma Warbrick and Stuart A MacNeill

    Citation: BMC Molecular Biology 2004 5:21

    Content type: Research article

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  17. Methyl-DNA binding proteins help to translate epigenetic information encoded by DNA methylation into covalent histone modifications. MBD2/3 is the only candidate gene in the Drosophila genome with extended homolo...

    Authors: Joachim Marhold, Alexander Brehm and Katja Kramer

    Citation: BMC Molecular Biology 2004 5:20

    Content type: Research article

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  18. The expression of glucocorticoid-receptor (GR) seems to be a key mechanism in the regulation of glucocorticoid (GC) sensitivity and is potentially involved in cases of GC resistance or hypersensitivity. The ai...

    Authors: Murilo R Melo, Cláudia DC Faria, Keli C Melo, Nancy A Rebouças and Carlos A Longui

    Citation: BMC Molecular Biology 2004 5:19

    Content type: Methodology article

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  19. The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification of clock genes has allowed us to study the molecular b...

    Authors: Takuro Yamamoto, Yasukazu Nakahata, Haruhiko Soma, Makoto Akashi, Takayoshi Mamine and Toru Takumi

    Citation: BMC Molecular Biology 2004 5:18

    Content type: Research article

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  20. Foamy virus Bel1/Tas trans-activators act as key regulators of gene expression and directly bind to Bel1 response elements (BRE) in both the internal and the 5'LTR promoters leading to strong transcriptional tran...

    Authors: Helmut Bannert, Walter Muranyi, Vasily V Ogryzko, Yoshihiro Nakatani and Rolf M Flügel

    Citation: BMC Molecular Biology 2004 5:16

    Content type: Research article

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  21. Hepatic expression of several gene products involved in glucose metabolism, including phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-like growth factor binding protein-1 ...

    Authors: David Finlay, Satish Patel, Lorna M Dickson, Natalia Shpiro, Rodolfo Marquez, Chris J Rhodes and Calum Sutherland

    Citation: BMC Molecular Biology 2004 5:15

    Content type: Research article

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  22. The periodic pattern of DNA in exons is a known phenomenon. It was suggested that one of the initial causes of periodicity could be the universal (RNY) n pattern (R = A or G,...

    Authors: Stephen T Eskesen, Frank N Eskesen, Brian Kinghorn and Anatoly Ruvinsky

    Citation: BMC Molecular Biology 2004 5:12

    Content type: Research article

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  23. p68 (Ddx5) and p72 (Ddx17) are highly related members of the DEAD box family and are established RNA helicases. They have been implicated in growth regulation and have been shown to be involved in both pre-mRN...

    Authors: Brian J Wilson, Gaynor J Bates, Samantha M Nicol, David J Gregory, Neil D Perkins and Frances V Fuller-Pace

    Citation: BMC Molecular Biology 2004 5:11

    Content type: Research article

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  24. Most of the existing RNA structure prediction programs fold a completely synthesized RNA molecule. However, within the cell, RNA molecules emerge sequentially during the directed process of transcription. Dedi...

    Authors: Irmtraud M Meyer and István Miklós

    Citation: BMC Molecular Biology 2004 5:10

    Content type: Research article

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  25. Incorporation of exon 11 of the insulin receptor gene is both developmentally and hormonally-regulated. Previously, we have shown the presence of enhancer and silencer elements that modulate the incorporation ...

    Authors: Nicholas JG Webster, Lui-Guojing Evans, Matt Caples, Laura Erker and Shern L Chew

    Citation: BMC Molecular Biology 2004 5:7

    Content type: Research article

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  26. Although the complete genome sequences of a large number of organisms have been determined, the exact proteomes need to be characterized. More specifically, the extent to which post-translational processes suc...

    Authors: Rajinder Kumar, Alla Musiyenko, Anja Oldenburg, Brian Adams and Sailen Barik

    Citation: BMC Molecular Biology 2004 5:6

    Content type: Research article

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  27. Exposure of Leishmania promastigotes to the temperature of their mammalian hosts results in the induction of a typical heat shock response. It has been suggested that heat shock proteins play an important role in...

    Authors: Ruth Larreta, Manuel Soto, Luis Quijada, Cristina Folgueira, Daniel R Abanades, Carlos Alonso and Jose M Requena

    Citation: BMC Molecular Biology 2004 5:3

    Content type: Research article

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  28. Despite the importance of glucocorticoids in suppressing immune and inflammatory responses, their role in enhancing host immune and defense response against invading bacteria is poorly understood. Toll-like re...

    Authors: Akihiro Sakai, Jiahuai Han, Andrew CB Cato, Shizuo Akira and Jian-Dong Li

    Citation: BMC Molecular Biology 2004 5:2

    Content type: Research article

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  29. The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well known, although knockout of the gene in Drosophila, or ...

    Authors: Gulshan Sunavala-Dossabhoy, Marcie Fowler and Arrigo De Benedetti

    Citation: BMC Molecular Biology 2004 5:1

    Content type: Research article

    Published on:

  30. The Wnt signaling pathway plays critical roles in cell proliferation and cell fate determination at many stages of development. A critical downstream target of Wnt signaling is the cytosolic β-catenin, which i...

    Authors: Feng Cong, Jianxuan Zhang, William Pao, Pengbo Zhou and Harold Varmus

    Citation: BMC Molecular Biology 2003 4:10

    Content type: Research article

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  31. Pifithrin-α is a small molecule inhibitor of p53 transcriptional activity. It has been proposed that the use of pifithrin-α in conjunction with chemotherapeutic and radiation therapies for cancer will reduce t...

    Authors: Sonia Rocha, Kirsteen J Campbell, Kevin C Roche and Neil D Perkins

    Citation: BMC Molecular Biology 2003 4:9

    Content type: Research article

    Published on: