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Transcriptional control of gene expression

Section edited by Jean-Francois Beaulieu

This section will consider submissions that focus on the analysis of gene expression levels and patterns, transcription mechanisms and the regulation of transcription.

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  1. The transcription factor Pax8 is expressed during thyroid development and is involved in the morphogenesis of the thyroid gland and maintenance of the differentiated phenotype. In particular, Pax8 has been shown ...

    Authors: Maria Grazia Filippone, Tina Di Palma, Valeria Lucci and Mariastella Zannini

    Citation: BMC Molecular Biology 2014 15:21

    Content type: Research article

    Published on:

  2. As a novel candidate metastasis suppressor gene, Nasopharyngeal carcinoma-associated gene 6 (NGX6) is involved in cellular growth, cell cycle progression and tumor angiogenesis. Previous studies have shown tha...

    Authors: Minji Liu, Xiaoyan Wang, Ya Peng, Shourong Shen and Guiyuan Li

    Citation: BMC Molecular Biology 2014 15:14

    Content type: Research article

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  3. Human mesenchymal stromal cells from the bone marrow (BMSCs) are widely used as experimental regenerative treatment of ischemic heart disease, and the first clinical trials using adipose-derived stromal cells ...

    Authors: Josefine Tratwal, Bjarke Follin, Annette Ekblond, Jens Kastrup and Mandana Haack-Sørensen

    Citation: BMC Molecular Biology 2014 15:11

    Content type: Methodology article

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  4. Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information is available on either the mechanisms or functional impact of the coupl...

    Authors: Ezequiel Calvo, Adrienne Grzenda, Gwen Lomberk, Angela Mathison, Juan Iovanna and Raul Urrutia

    Citation: BMC Molecular Biology 2014 15:10

    Content type: Research article

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  5. YBX3/ZONAB/CSDA is an epithelial-specific transcription factor acting in the density-based switch between proliferation and differentiation. Our laboratory reported overexpression of YBX3 in clear cell renal c...

    Authors: Sébastien Dupasquier, Anne-Sophie Delmarcelle, Etienne Marbaix, Jean-Pierre Cosyns, Pierre J Courtoy and Christophe E Pierreux

    Citation: BMC Molecular Biology 2014 15:9

    Content type: Research article

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  6. Krüppel-like Factor 3 (KLF3) is a broadly expressed zinc-finger transcriptional repressor with diverse biological roles. During erythropoiesis, KLF3 acts as a feedback repressor of a set of genes that are acti...

    Authors: Alister PW Funnell, Douglas Vernimmen, Wooi F Lim, Ka Sin Mak, Beeke Wienert, Gabriella E Martyn, Crisbel M Artuz, Jon Burdach, Kate GR Quinlan, Douglas R Higgs, Emma Whitelaw, Richard CM Pearson and Merlin Crossley

    Citation: BMC Molecular Biology 2014 15:8

    Content type: Research article

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  7. In vertebrates, rod photoreceptor-specific gene expression is regulated by the large Maf and Pax-like transcription factors, Nrl/LNrl and Crx/Otx5. The ubiquitous occurrence of their target DNA binding sites t...

    Authors: Sarah E Reks, Vera McIlvain, Xinming Zhuo and Barry E Knox

    Citation: BMC Molecular Biology 2014 15:4

    Content type: Research article

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  8. GATA transcription factors are essential for self-renewal of the small intestinal epithelium. Gata4 is expressed in the proximal 85% of small intestine while Gata6 is expressed throughout the length of small inte...

    Authors: Boaz E Aronson, Kelly A Stapleton, Laurens ATM Vissers, Eva Stokhuijzen, Hanneke Bruijnzeel and Stephen D Krasinski

    Citation: BMC Molecular Biology 2014 15:3

    Content type: Research article

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  9. MicroRNAs (miRNAs) are a family of small, non-coding single-stranded RNA molecules involved in post-transcriptional regulation of gene expression. As such, they are believed to play a role in regulating the st...

    Authors: Marlinda Hupkes, Ana M Sotoca, José M Hendriks, Everardus J van Zoelen and Koen J Dechering

    Citation: BMC Molecular Biology 2014 15:1

    Content type: Research article

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  10. Previously we have identified a distal region of the rainbow trout (Oncorhynchus mykiss) metallothionein-A (rtMT-A) enhancer region, being essential for free radical activation of the rtMT-A gene. The distal prom...

    Authors: Peter Kling, Carina Modig, Huthayfa Mujahed, Hazem Khalaf, Jonas von Hofsten and Per-Erik Olsson

    Citation: BMC Molecular Biology 2013 14:28

    Content type: Research article

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  11. Aryl hydrocarbon receptor (AhR) not only regulates drug-metabolizing enzyme expression but also regulates cancer malignancy. The steps to the development of malignancy include angiogenesis that is induced by t...

    Authors: Jun Terashima, Chie Tachikawa, Kenzo Kudo, Wataru Habano and Shogo Ozawa

    Citation: BMC Molecular Biology 2013 14:27

    Content type: Research article

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  12. The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used to assess the expression of prophylactic or therapeutic genes in animal disease models.

    Authors: Stefania Puttini, Ruthger W van Zwieten, Damien Saugy, Małgorzata Lekka, Florence Hogger, Deborah Ley, Andrzej J Kulik and Nicolas Mermod

    Citation: BMC Molecular Biology 2013 14:26

    Content type: Methodology article

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  13. Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ...

    Authors: Katie Rose Boissonneault, Brooks M Henningsen, Stephen S Bates, Deborah L Robertson, Sean Milton, Jerry Pelletier, Deborah A Hogan and David E Housman

    Citation: BMC Molecular Biology 2013 14:25

    Content type: Research article

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  14. Selecting stably expressed reference genes is essential for proper reverse transcription quantitative polymerase chain reaction gene expression analysis. However, this choice is not always straightforward. In ...

    Authors: Liesbeth Vossaert, Thomas O’Leary, Christophe Van Neste, Björn Heindryckx, Jo Vandesompele, Petra De Sutter and Dieter Deforce

    Citation: BMC Molecular Biology 2013 14:21

    Content type: Research article

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  15. Valuable clone collections encoding the complete ORFeomes for some model organisms have been constructed following the completion of their genome sequencing projects. These libraries are based on Gateway cloni...

    Authors: Raquel Buj, Noa Iglesias, Anna M Planas and Tomàs Santalucía

    Citation: BMC Molecular Biology 2013 14:18

    Content type: Methodology article

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  16. Flower colour variation is one of the most crucial selection criteria in the breeding of a flowering pot plant, as is also the case for azalea (Rhododendron simsii hybrids). Flavonoid biosynthesis was studied int...

    Authors: Ellen De Keyser, Laurence Desmet, Erik Van Bockstaele and Jan De Riek

    Citation: BMC Molecular Biology 2013 14:13

    Content type: Research article

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  17. RA (retinoic acid) signal pathway has been proved to be required for germ cell meiotic initiation in mammals, aves and amphibians. Stra8 (Stimulated by retinoic acid gene 8) is an important factor in RA signal...

    Authors: Ranran Dong, Shijie Yang, Jing Jiao, Tingru Wang, Hongjuan Shi, Linyan Zhou, Yaoguang Zhang and Deshou Wang

    Citation: BMC Molecular Biology 2013 14:11

    Content type: Research article

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  18. The ability to interrogate circulating tumor cells (CTC) and disseminated tumor cells (DTC) is restricted by the small number detected and isolated (typically <10). To determine if a commercially available tec...

    Authors: Christopher J Welty, Ilsa Coleman, Roger Coleman, Bryce Lakely, Jing Xia, Shu Chen, Roman Gulati, Sandy R Larson, Paul H Lange, Bruce Montgomery, Peter S Nelson, Robert L Vessella and Colm Morrissey

    Citation: BMC Molecular Biology 2013 14:6

    Content type: Methodology article

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  19. T-cell intracellular antigen (TIA) proteins function as regulators of cell homeostasis. These proteins control gene expression globally at multiple levels in response to dynamic regulatory changes and environm...

    Authors: Carmen Sánchez-Jiménez, Isabel Carrascoso, Juan Barrero and José M Izquierdo

    Citation: BMC Molecular Biology 2013 14:4

    Content type: Research article

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  20. Duchenne muscular dystrophy (DMD) is the most common X-linked muscle degenerative disease and it is due to the absence of the cytoskeletal protein dystrophin. Currently there is no effective treatment for DMD....

    Authors: Annalisa Onori, Cinzia Pisani, Georgios Strimpakos, Lucia Monaco, Elisabetta Mattei, Claudio Passananti and Nicoletta Corbi

    Citation: BMC Molecular Biology 2013 14:3

    Content type: Research article

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  21. GAD65 (Glutamic acid decarboxylase 65 KDa isoform) is one of the most important auto-antigens involved in Type 1 diabetes induction. Although it serves as one of the first injury markers of β-islets, the mecha...

    Authors: Sandeep Singh, Varsheish Raina, Pavithra Lakshminarsimhan Chavali, Taronish Dubash, Sreenath Kadreppa, Pradeep Parab and Samit Chattopadhyay

    Citation: BMC Molecular Biology 2012 13:28

    Content type: Research article

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  22. miR-34a functions as an important tumor suppressor during the process of carcinogenesis. However, the mechanism of miR-34a dysregulation in human malignancies has not been well elucidated. Our study aimed to f...

    Authors: Juan Li, Kai Wang, Xuedan Chen, Hui Meng, Min Song, Yan Wang, Xueqing Xu and Yun Bai

    Citation: BMC Molecular Biology 2012 13:4

    Content type: Research article

    Published on: