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Fig. 9 | BMC Molecular Biology

Fig. 9

From: PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism

Fig. 9

Overview of the regulatory mechanism of PSMD1 and PSMD2 that regulates tumor cell proliferation. Briefly, PSMD1 and PSMD2 regulate the phosphorylation of ASK1-p38-JNK and AKT signaling. Then, the expression level of SREBF1 and PPARγ is regulated. Subsequently, these two important transcriptional factors regulate the expression levels of FAs and lipid synthesis-related genes such as FASN, SCD1, ASCL, DGAT and PLIN. The upregulation of these genes induces more lipid droplet (LD) formation, whereas LDs can provide membrane components and energy for cell proliferation. Therefore, PSMD1 and PSMD2 regulate cell proliferation via modulating cellular lipid metabolism

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