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Table 2 The top 10 enriched biological process, cell component and molecular function GO terms for DEGs, which were sorted respectively by p-value in ascending

From: MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells

Category Term Count p-value Fold enrichment
GOTERM_BP_DIRECT GO:0007565 ~ female pregnancy 13 2.86E−04 3.534242
GOTERM_BP_DIRECT GO:0007267 ~ cell–cell signaling 24 3.61E−04 2.286233
GOTERM_BP_DIRECT GO:0008152 ~ metabolic process 18 5.93E−04 2.592425
GOTERM_BP_DIRECT GO:0007165 ~ signal transduction 69 0.002168 1.438003
GOTERM_BP_DIRECT GO:0001525 ~ angiogenesis 20 0.002302 2.170042
GOTERM_BP_DIRECT GO:0008277 ~ regulation of G-protein coupled receptor protein signaling pathway 7 0.00493 4.342866
GOTERM_BP_DIRECT GO:0030168 ~ platelet activation 12 0.007956 2.524796
GOTERM_BP_DIRECT GO:0006687 ~ glycosphingolipid metabolic process 7 0.009997 3.763817
GOTERM_BP_DIRECT GO:0071526 ~ semaphorin–plexin signaling pathway 6 0.010737 4.399266
GOTERM_BP_DIRECT GO:0016266 ~ O-glycan processing 8 0.011451 3.226129
GOTERM_CC_DIRECT GO:0005615 ~ extracellular space 109 1.54E−11 1.95324
GOTERM_CC_DIRECT GO:0005576 ~ extracellular region 123 2.57E−11 1.844064
GOTERM_CC_DIRECT GO:0005886 ~ plasma membrane 214 1.33E−04 1.253453
GOTERM_CC_DIRECT GO:0005578 ~ proteinaceous extracellular matrix 25 3.33E−04 2.251656
GOTERM_CC_DIRECT GO:0016021 ~ integral component of membrane 251 0.001739 1.17346
GOTERM_CC_DIRECT GO:0005581 ~ collagen trimer 11 0.004686 2.886035
GOTERM_CC_DIRECT GO:0009986 ~ cell surface 36 0.00631 1.603245
GOTERM_CC_DIRECT GO:0005887 ~ integral component of plasma membrane 76 0.015603 1.296444
GOTERM_CC_DIRECT GO:0002177 ~ manchette 3 0.015728 14.48265
GOTERM_CC_DIRECT GO:0005884 ~ actin filament 8 0.017555 2.9708
GOTERM_MF_DIRECT GO:0046934 ~ phosphatidylinositol-4,5-bisphosphate 3-kinase activity 10 8.46E−04 3.963234
GOTERM_MF_DIRECT GO:0005125 ~ cytokine activity 18 8.47E−04 2.513051
GOTERM_MF_DIRECT GO:0004867 ~ serine-type endopeptidase inhibitor activity 12 0.001915 3.039842
GOTERM_MF_DIRECT GO:0008083 ~ growth factor activity 16 0.002531 2.426869
GOTERM_MF_DIRECT GO:0008201 ~ heparin binding 15 0.005735 2.30363
GOTERM_MF_DIRECT GO:0008401 ~ retinoic acid 4-hydroxylase activity 3 0.009368 18.42904
GOTERM_MF_DIRECT GO:0005102 ~ receptor binding 25 0.009977 1.74023
GOTERM_MF_DIRECT GO:0005509 ~ calcium ion binding 42 0.017368 1.439367
GOTERM_MF_DIRECT GO:0032395 ~ MHC class II receptor activity 4 0.021097 6.552547
GOTERM_MF_DIRECT GO:0001665 ~ alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity 3 0.022182 12.28603