Fig. 4

The functional association protein networks were constructed with STRING for the DEGs. Settings for the interaction search as follows: minimum required interaction score is ≥ 0.7 (high confidence); active interaction sources are Textmining, Experiments, Databases, Co-expression, Neighborhood, Gene Fusion and Co-occurrence; the max number of interactors to show is query proteins only for the first shell and none for the second shell; hide the disconnected nodes in the network. The pies indicated nodes and the full line indicated the edges of the PPI network. a Network for down-regulated genes. b Network for UP-regulated genes