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Table 6 Genes regulated in the domoic acid (DA) induced grazer treatments that are involved or suggested to be involved in the biosynthesis of DA

From: Transcriptomic responses to grazing reveal the metabolic pathway leading to the biosynthesis of domoic acid and highlight different defense strategies in diatoms

Domoic acid
Accession number Mean FC Adjusted P value Gene name Description Enzyme EC:
In the methylerythritol phosphate metabolic pathway (MEP) to geranyl pyrophosphate (GPP)
 PSN0016235 1.88 < 0.001 Dxr 1-Deoxy-d-xylulose 5-phosphate reductoisomerase 1.1.1.267
 PSN0004050 1.82 < 0.001 ispH 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase 1.17.1.2
 PSN0005356 1.61 0.043 ispG 4-Hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1.17.7.1
 PSN0002600 1.60 < 0.001 ispD 2-C-Methyl-d-erythritol 4-phosphate cytidylyltransferase, chloroplastic 2.7.7.60
 PSN0023754 1.60 0.013 ispE 4-Diphosphocytidyl-2-C-methyl-d-erythritol kinase 2.7.1.148
In the synthesis from MEP to GPP and l-glutamate towards domoic acid
 PSN0015669 12.23 < 0.001 DabB Hypothetical protein NA
 PSN0029114 + PSN002498 11.23 < 0.001 DabC Dioxygenase NA
 PSN0007588 9.41 < 0.001 DabA N-prenyltransferase NA
 PSN0005772 2.83 <0.001 idi1-2 Isopentenyl-diphosphate Delta-isomerase 5.3.3.2
 PSN0020364 2.83 < 0.001 DabD Cytochrome P450 NA
Proline metabolism
 PSN0000830 1.67 < 0.001 P4HA Prolyl 4-hydroxylase 1.14.11.2
 PSN0001687 1.62 0.002 NA Ornithine cyclodeaminase 4.3.1.12
  1. Mean fold change (FC) and adjusted P values are based on three replicates