MiRNAs differentially expressed in skeletal muscle of animals with divergent estimated breeding values for beef tenderness

Table 6 Characterization of few candidate canonical pathways for meat tenderness

Canonical Pathway	miRNA^a	Target genes
Apoptosis signaling	bta-mir-182	ROCK1, CAPN5, CASP2, MRAS, PRKCE, CYCS, BCL2
Apoptosis signaling	bta-mir-338	CAPN5
Glutathione biosynthesis	bta-mir-183	GCLM
Regulation of cellular mechanics by calpain protease	bta-mir-182	CAPN5, GRB2, EZR, MRAS, VCL, CAST
	bta-mir-183	ITGB1, EZR
	bta-mir-338	CAPN5
Calcium signaling	bta-mir-182	HDAC9, NFAT5, HDAC2, GRIA1, PPP3R1, CREB1, HDAC7, MEF2C, PPP3CA, CAMKK2, GRIA3, PRKAR1A
	bta-mir-183	CAMK2D, ATP2C1, SLC8A2, TPM1, MEF2C, ATP2B4
	bta-mir-338	TP63, CAMK2A, MEF2C, TPM4, CAMK2G
Calcium transport I	bta-mir-183	ATP2C1, ATP2B4

^amiRNAs that exhibited the respective significative canonical pathways based on the list of target genes provided

ISSN: 1471-2199