Molecular analysis of NPAS3 functional domains and variants

BMC Molecular Biology

Table 1 Potential co-targets of NPAS3 and ARNT screened in this study

Gene name	ENCODE ARNT ChIP-seq peaks^a	Fold regulation by NPAS3^b	Other identifiers	Functions
VGF	3	2.92		Dendritic arborization, proneurogenic [35, 36]
HIST1H4H	5	2.05	Histone H4	G1-S transition, replication licencing factors [37]
ATF5	5	1.83		Cell cycle progression G1-S, stress response, cAMP signalling, SVZ neurogenesis [38, 39]
DHCR24	5	1.75	Seladin-1	Neuroprotective, oxidative stress, inflammation [40]
ZBTB40	5	1.74		Unknown
NCLN	5	1.70	Nicalin	Nicalin-NOMO complex, nodal signalling [41]
MAT2A	5	1.67		S-adenosylmethionine synthesis, hypoxia [42]
USP49	5	− 2.10		Deubiquitinase [43]
ANG	5	− 2.16	RNASE5	Alternate ORF transcribed from RNASE4 [44]
ZNF581	5	− 2.24		Unknown
RPL37	5	− 2.33		p53 pathway, MDM2, MDMX [45]
RNASE4	5	− 2.40		Neuroprotective during oxidative stress [44]
TXNIP	5	− 2.57		Oxidative stress response, inflammation [46]
ANKRD37	5	− 4.49		Hypoxia [47, 48]

^aScore out of 5 based on calling of peaks in all replicate analyses of the ARNT ChIP-seq data from the ENCODE project experiment ENCSR155KHM
^bRegulation observed in [25]

ISSN: 1471-2199