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Table 3 Breakpoints identified within the AF9 SAR region in H2O2-treated cells

From: Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis

Cell line treated with H2O2

Breakpoint

Remarks

NP69

245,566

This chromosome break was detected within the AF9 region (at coordinates 245,252–245,612) which was previously found to take part in the MLL-AF9 translocation in an ALL patient [GenBank:AM050804]. This breakpoint is 46 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,591

This chromosome break was detected within the AF9 region (at coordinates 245,252–245,612) which was previously found to take part in the MLL-AF9 translocation in an ALL patient [GenBank:AM050804]. This breakpoint is two nucleotides different from that reported in cultured normal blood cells treated with VP16 (at coordinate 245,593) [35] and 21 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,645

This breakpoint is 33 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,659

This breakpoint is 47 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,711

 

245,730

 

245,804

 

245,817

 

245,826

 

245,842

 

245,959

 

245,970

 

246,089

 

HK1

245,560

This chromosome break was detected within the AF9 region (at coordinates 245,252–245,612) which was previously found to take part in the MLL-AF9 translocation in an ALL patient [GenBank:AM050804]. This breakpoint is 52 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,634

This breakpoint is 22 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,681

This breakpoint is 69 nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]

245,755

 

245,949

 
  1. The nucleotide positions of the chromosome breaks identified within the AF9 SAR region were mapped according to the AF9 sequence retrieved from Ensembl database [EMBL:ENSG00000171843]