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Table 1 MAR/SARs predicted within the AF9 gene by using MRS

From: Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis

Predicted MAR/SAR AWWRTAANNWWGNNNC (16 bp) Nucleotide position AATAAYAA (8 bp) Nucleotide position Distance (bp) Location in exon/intron
1 ATAATAATAAAAGCCC (C) 916–931 AATAATAA (C)
AATAATAA (C)
915–922
918–925
Overlap
Overlap
Intron 1
2 ATAGTAAGGATGGCTG (W) 5636–5651 AATAATAA (W) 5694–5701 42 Intron 2
3 AAAATAACAAAGGAAG (W) 10,555–10,570 AATAACAA (W) 10,561–10,568 Overlap Intron 2
4 AATATTATTATGGGTC (W) 26,366–26,381 AATAATAA (W) 26,420–26,427 38 Intron 2
5 AAAGTAAACTGGAAAC (C) 47,851–47,866 AATAACAA (W) 47,627–47,634 − 216 Intron 2
6 AAAATAATAATAATAC (W) 56,224–56,239 AATAATAA (W)
AATAATAA (W)
56,227–56,234
56,230–56,237
Overlap
Overlap
Intron 2
7 AAAATCATCTTGGGAC (W) 94,045–94,060 AATAACAA (W) 93,895–93,902 − 142 Intron 2
8 AAAATAATAAAAACCC (C) 108,633–108,648 AATAATAA (C) 108,635–108,642 Overlap Intron 2
9-1 ATAATAACATTTTACC (C) 112,369–112,384 AATAATAA (C) 112,368–112,375 Overlap Intron 2
9-2 AAAATAATAATTGTAC (C) 113,269–113,284 AATAATAA (C) 113,271–113,278 Overlap Intron 2
10 ATTGGAATGTAGAAAC (W) 117,722–117,737 AATAACAA (W) 117,606–117,613 − 108 Intron 2
11-1 AATATAATCTAATTGC (W) 128,593–128,608 AATAACAA (C) 128,355–128,362 − 230 Intron 2
11-2 AAAATAAGTTTCCAGC (W) 129,838–129,853 AATAACAA (C)
AATAATAA (C)
129,941–129,948
129,980–129,987
87
126
Intron 2
12 ATAATAATAAAATCAC (W) 136,176–136,191 AATAATAA (W) 136,182–136,189 Overlap Intron 2
13 AATATAATGAATATCC (C) 139,927–139,942 AATAATAA (C)
AATAATAA (C)
AATAATAA (C)
AATAATAA (C)
139,902–139,909
139,905–139,912
139,908–139,915
139,911–139,918
− 17
− 14
− 11
− 8
Intron 2
14 TTTATAAACTTGTTTC (C) 151,672–151,687 AATAATAA (W) 151,857–151,864 169 Intron 2
15 AAAATAAAAAAGAGCT (C) 158,541–158,556 AATAATAA (W) 158,593–158,600 46 Intron 2
16 AAAATAATAAATACGC (W) 170,523–170,538 AATAATAA (W)
AATAACAA (W)
170,529–170,536
170,619–170,626
Overlap
80
Intron 3a
17-1 ATAATAAATATGAATA (W) 178,638–178,653 AATAATAA (W) 178,634–178,641 Overlap Intron 3b
17-2 AAAAGAACTAAGGTAC (W) 179,378–179,393 AATAATAA (W) 179,140–179,147 − 230 Intron 3b
18 AAGGTAAATTAGCAGC (W)
ATAATAATAATGTTCT (C)
ATAATAATGTTCTACC (C)
182,936–182,951
183,171–183,186
183,174–183,189
AATAATAA (C) 183,173–183,180 221
Overlap
Overlap
Intron 3b
19 ATTATAAGAAAAATTC (W)
ATAATAAAAATGTTAT (C)
ATAATGATCAAGTACC (C)
191,065–191,080
191,076–191,091
191,548–191,563
AATAATAA (W) 191,323–191,330 242
231
− 217
Intron 3b
20-1 AAAATAAGAAAACATC (W)
AATATAATTATGCTAA (W)
194,333–194,348
194,753–194,768
AATAATAA (W) 194,511–194,518 162
− 234
Intron 3b
20-2 AATATAAAATTGCAAG (W) 195,275–195,290 AATAATAA (C) 195,198–195,205 − 69 Intron 3b
21 AAAATAATAAAGCCAT (W) 200,768–200,783 AATAATAA (W) 200,774–200,781 Overlap Intron 3b
22-1 ATAATAATAATAATAC (W) 215,365–215,380 AATAATAA (W)
AATAATAA (W)
AATAATAA (W)
215,368–215,375
215,371–215,378
215,374–215,381
Overlap
Overlap
Overlap
Intron 4
22-2 AAAATAAAACTGACTC (C)
ATAATTACATAGACAC (W)
215,781–215,796
216,113–216,128
AATAACAA (C) 215,941–215,948 144
− 164
Intron 4
23 ATAATAATAATGAAAG (C) 227,849–227,864 AATAATAA (C)
AATAATAA (C)
227,848–227,855
227,851–227,858
Overlap
Overlap
Intron 4
24-1 ATAATAAGTTATAGGC (W) 236,299–236,314 AATAATAA (W)
AATAATAA (C)
236,308–236,315
236,343–236,350
Overlap
28
Intron 4
24-2 AAAATAACAAAATGTC (W)
AATGTAAGCAATATCC (W)
237,605–237,620
237,817–237,832
AATAACAA (W) 237,611–237,618 Overlap
− 198
Intron 4
24-3 AATGTAAGCAATATCC (W) AAAGTATTGTAGACCC (C)
AAAATAATAAAGGGGT (W)
237,817–237,832
237,983–237,998
237,995–238,010
AATAATAA (W) 238,001–238,008 168
2
Overlap
Intron 4
24-4 TATATAATAAAGTGAC (C) 238,794–238,809 AATAATAA (W) 239,050–239,057 240 Intron 4
25-1 ATAATAATGAAGAAAG (C) 246,610–246,625 AATAATAA (C) 246,588–246,595 − 14 Intron 4
25-2 ATTGTAATATTGATTG (C)
AATATTACAATGAATC (W)
TTTATAAATTAGGGAC (W)
247,587–247,602
247,582–247,597
247,758–247,773
AATAACAA (C) 247,561–247,568 − 18
− 13
− 189
Intron 4
26-1 AAAGTAAATAAAAAAC (W) 251,265–251,280 AATAATAA (C) 251,344–251,351 63 Intron 4
26-2 AATGAAAGGAAGAGCC (W)
ATAATAATAATGAAAA (C)
252,636–252,651
252,891–252,906
AATAATAA (C) 252,893–252,900 241
Overlap
Intron 4
27 ATAATAAACTACCATC (W)
ATAATAATAAACTACC (W)
AAAATAAACTATTTTC (C)
262,931–262,946
262,934–262,949
263,198–263,213
AATAATAA (W) 262,940–262,947 Overlap
Overlap
− 250
Intron 7
28-1 AATATAATCTTGAACG (C) 265,612–265,627 AATAATAA (C) 265,768–265,775 140 Intron 7
28-2 AAAATAAAAATATGCC (C)
AATAAAAATATGCCCC (C)
ATAATAAGGCTGGGAC (C)
ATTTTAAGAATGAGTC (W)
AAGATAAATTAGGTCC (C)
266,963–266,978
266,965–266,980
267,134–267,149
267,205–267,220
267,317–267,332
AATAATAA (C) 267,133–267,140 154
152
Overlap
− 64
− 176
Intron 7
28-3 AAGATAAATTAGGTCC (C) 267,317–267,332 AATAATAA (C) 267,569–267,576 236 Intron 7
29 AAAAAAAAATTGTAAC (W) 273,593–273,608 AATAACAA (W) 273,528–273,535 − 57 Intron 9
  1. Nucleotide positions of the MRSs with their sequence composition, relative orientation (C: Crick strand and W: Watson strand), distance between the two sequence elements and location of the MRSs in the exon or intron of the AF9 gene are shown. A negative distance indicates that 8 bp sequence element precedes the 16 bp sequence element