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Table 1 MAR/SARs predicted within the AF9 gene by using MRS

From: Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis

Predicted MAR/SAR AWWRTAANNWWGNNNC (16 bp) Nucleotide position AATAAYAA (8 bp) Nucleotide position Distance (bp) Location in exon/intron
1 ATAATAATAAAAGCCC (C) 916–931 AATAATAA (C) AATAATAA (C) 915–922 918–925 Overlap Overlap Intron 1
2 ATAGTAAGGATGGCTG (W) 5636–5651 AATAATAA (W) 5694–5701 42 Intron 2
3 AAAATAACAAAGGAAG (W) 10,555–10,570 AATAACAA (W) 10,561–10,568 Overlap Intron 2
4 AATATTATTATGGGTC (W) 26,366–26,381 AATAATAA (W) 26,420–26,427 38 Intron 2
5 AAAGTAAACTGGAAAC (C) 47,851–47,866 AATAACAA (W) 47,627–47,634 − 216 Intron 2
6 AAAATAATAATAATAC (W) 56,224–56,239 AATAATAA (W) AATAATAA (W) 56,227–56,234 56,230–56,237 Overlap Overlap Intron 2
7 AAAATCATCTTGGGAC (W) 94,045–94,060 AATAACAA (W) 93,895–93,902 − 142 Intron 2
8 AAAATAATAAAAACCC (C) 108,633–108,648 AATAATAA (C) 108,635–108,642 Overlap Intron 2
9-1 ATAATAACATTTTACC (C) 112,369–112,384 AATAATAA (C) 112,368–112,375 Overlap Intron 2
9-2 AAAATAATAATTGTAC (C) 113,269–113,284 AATAATAA (C) 113,271–113,278 Overlap Intron 2
10 ATTGGAATGTAGAAAC (W) 117,722–117,737 AATAACAA (W) 117,606–117,613 − 108 Intron 2
11-1 AATATAATCTAATTGC (W) 128,593–128,608 AATAACAA (C) 128,355–128,362 − 230 Intron 2
11-2 AAAATAAGTTTCCAGC (W) 129,838–129,853 AATAACAA (C) AATAATAA (C) 129,941–129,948 129,980–129,987 87 126 Intron 2
12 ATAATAATAAAATCAC (W) 136,176–136,191 AATAATAA (W) 136,182–136,189 Overlap Intron 2
13 AATATAATGAATATCC (C) 139,927–139,942 AATAATAA (C) AATAATAA (C) AATAATAA (C) AATAATAA (C) 139,902–139,909 139,905–139,912 139,908–139,915 139,911–139,918 − 17 − 14 − 11 − 8 Intron 2
14 TTTATAAACTTGTTTC (C) 151,672–151,687 AATAATAA (W) 151,857–151,864 169 Intron 2
15 AAAATAAAAAAGAGCT (C) 158,541–158,556 AATAATAA (W) 158,593–158,600 46 Intron 2
16 AAAATAATAAATACGC (W) 170,523–170,538 AATAATAA (W) AATAACAA (W) 170,529–170,536 170,619–170,626 Overlap 80 Intron 3a
17-1 ATAATAAATATGAATA (W) 178,638–178,653 AATAATAA (W) 178,634–178,641 Overlap Intron 3b
17-2 AAAAGAACTAAGGTAC (W) 179,378–179,393 AATAATAA (W) 179,140–179,147 − 230 Intron 3b
18 AAGGTAAATTAGCAGC (W) ATAATAATAATGTTCT (C) ATAATAATGTTCTACC (C) 182,936–182,951 183,171–183,186 183,174–183,189 AATAATAA (C) 183,173–183,180 221 Overlap Overlap Intron 3b
19 ATTATAAGAAAAATTC (W) ATAATAAAAATGTTAT (C) ATAATGATCAAGTACC (C) 191,065–191,080 191,076–191,091 191,548–191,563 AATAATAA (W) 191,323–191,330 242 231 − 217 Intron 3b
20-1 AAAATAAGAAAACATC (W) AATATAATTATGCTAA (W) 194,333–194,348 194,753–194,768 AATAATAA (W) 194,511–194,518 162 − 234 Intron 3b
20-2 AATATAAAATTGCAAG (W) 195,275–195,290 AATAATAA (C) 195,198–195,205 − 69 Intron 3b
21 AAAATAATAAAGCCAT (W) 200,768–200,783 AATAATAA (W) 200,774–200,781 Overlap Intron 3b
22-1 ATAATAATAATAATAC (W) 215,365–215,380 AATAATAA (W) AATAATAA (W) AATAATAA (W) 215,368–215,375 215,371–215,378 215,374–215,381 Overlap Overlap Overlap Intron 4
22-2 AAAATAAAACTGACTC (C) ATAATTACATAGACAC (W) 215,781–215,796 216,113–216,128 AATAACAA (C) 215,941–215,948 144 − 164 Intron 4
23 ATAATAATAATGAAAG (C) 227,849–227,864 AATAATAA (C) AATAATAA (C) 227,848–227,855 227,851–227,858 Overlap Overlap Intron 4
24-1 ATAATAAGTTATAGGC (W) 236,299–236,314 AATAATAA (W) AATAATAA (C) 236,308–236,315 236,343–236,350 Overlap 28 Intron 4
24-2 AAAATAACAAAATGTC (W) AATGTAAGCAATATCC (W) 237,605–237,620 237,817–237,832 AATAACAA (W) 237,611–237,618 Overlap − 198 Intron 4
24-3 AATGTAAGCAATATCC (W) AAAGTATTGTAGACCC (C) AAAATAATAAAGGGGT (W) 237,817–237,832 237,983–237,998 237,995–238,010 AATAATAA (W) 238,001–238,008 168 2 Overlap Intron 4
24-4 TATATAATAAAGTGAC (C) 238,794–238,809 AATAATAA (W) 239,050–239,057 240 Intron 4
25-1 ATAATAATGAAGAAAG (C) 246,610–246,625 AATAATAA (C) 246,588–246,595 − 14 Intron 4
25-2 ATTGTAATATTGATTG (C) AATATTACAATGAATC (W) TTTATAAATTAGGGAC (W) 247,587–247,602 247,582–247,597 247,758–247,773 AATAACAA (C) 247,561–247,568 − 18 − 13 − 189 Intron 4
26-1 AAAGTAAATAAAAAAC (W) 251,265–251,280 AATAATAA (C) 251,344–251,351 63 Intron 4
26-2 AATGAAAGGAAGAGCC (W) ATAATAATAATGAAAA (C) 252,636–252,651 252,891–252,906 AATAATAA (C) 252,893–252,900 241 Overlap Intron 4
27 ATAATAAACTACCATC (W) ATAATAATAAACTACC (W) AAAATAAACTATTTTC (C) 262,931–262,946 262,934–262,949 263,198–263,213 AATAATAA (W) 262,940–262,947 Overlap Overlap − 250 Intron 7
28-1 AATATAATCTTGAACG (C) 265,612–265,627 AATAATAA (C) 265,768–265,775 140 Intron 7
28-2 AAAATAAAAATATGCC (C) AATAAAAATATGCCCC (C) ATAATAAGGCTGGGAC (C) ATTTTAAGAATGAGTC (W) AAGATAAATTAGGTCC (C) 266,963–266,978 266,965–266,980 267,134–267,149 267,205–267,220 267,317–267,332 AATAATAA (C) 267,133–267,140 154 152 Overlap − 64 − 176 Intron 7
28-3 AAGATAAATTAGGTCC (C) 267,317–267,332 AATAATAA (C) 267,569–267,576 236 Intron 7
29 AAAAAAAAATTGTAAC (W) 273,593–273,608 AATAACAA (W) 273,528–273,535 − 57 Intron 9
  1. Nucleotide positions of the MRSs with their sequence composition, relative orientation (C: Crick strand and W: Watson strand), distance between the two sequence elements and location of the MRSs in the exon or intron of the AF9 gene are shown. A negative distance indicates that 8 bp sequence element precedes the 16 bp sequence element