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Table 3 Biological processes found to be altered in both transcriptome and proteome datasets

From: Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link

Gene ontology Transcriptome Proteome
Total genes Diff. genes P-value FDR (%) Enr. Total genes Diff. genes P-value FDR (%) Enr.
GO:0003008—System_process 840 40 < 0.001 < 0.01 27 9 0.01 0.37 2.1
GO:0007267—Cell-cell_signaling 612 38 < 0.001 < 0.01 23 8 0.01 0.40 2.2
GO:0007268—Synaptic_transmission 297 31 < 0.001 < 0.01 18 7 0.01 0.58 2.4
GO:0019226—Transmission_of_nerve_impulse 326 33 < 0.001 < 0.01 20 7 0.02 0.43 2.2
GO:0023046—Signaling_process 1975 63 < 0.001 < 0.01 41 13 0.002 0.25 2
GO:0023060—Signal_transmission 1973 63 < 0.001 < 0.01 41 13 0.002 0.25 2
GO:0050877—Neurological_system_process 541 35 < 0.001 < 0.01 21 7 0.03 0.39 2.1
GO:0007154—Cell_communication 1174 41 0.001 < 0.01 32 9 0.04 0.36 1.8
GO:0007269—Neurotransmitter_secretion 50 8 0.002 < 0.01 5 3 0.03 0.45 3.8
GO:0023052—Signaling 2871 71 0.003 < 0.01 53 13 0.03 0.46 1.5
GO:0044057—Regulation_of_system_process 135 8 0.05 0.04 5 3 0.03 0.45 3.8
GO:0065008—Regulation_of_biological_quality 1443 21 0.05 0.02 2 49 12 0.05 0.35 1.5
  1. P-value corrected for multiple comparisons
  2. Diff. genes differentially expressed genes, Enr. enrichment; FDR False Discovery Rate calculated with one-sided Fisher exact