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Table 4 Candidate genes of interest in persistence based on upregulation in long-term (vs. short-term) samples

From: Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis

Locus tag

Product name/description

Log2 (fold change)

Listed as virulence gene?

BMEII1062

(S)-2-hydroxy-acid oxidase subunit GlcE

4.8

No

BMEII1029

3-Deoxy-d-manno-octulosonic-acid transferase

4.3

No

BMEI1927

Enoyl-CoA hydratase

4.1

No

BMEII0089

Ribokinase (rbsK)

4.1

Yes

BMEII0086

Galactoside transport system permease MglC

4.0

No

BMEI1816

Sensory transduction protein kinase

4.0

No

BMEII0524

Hypothetical protein

3.7

No

BMEII0860

Oligopeptide transport system permease protein AppB

3.7

No

BMEII0862

Dihydrodipicolinate synthase

3.6

No

BMEI0234

Hypothetical cytosolic protein

3.5

No

BMEI1766

Sulfite reductase (ferredoxin; cysI)

3.4

Yes

BMEII0527

Exodeoxyribonuclease VII large subunit (xseA)

3.4

Yes

BMEII0526

Transcriptional regulatory protein, LysR family

3.4

No

BMEI0171

Ribosomal protein L11 methyltransferase

3.4

No

BMEI1926

Hydroxymethylglutaryl-CoA lyase

3.4

No

BMEI1817

ATP_dependent helicase HrpB

3.3

No

BMEI0173

Ycil-like protein

3.3

No

BMEI1925

Acetyl-CoA carboxylase alpha chain/propionyl-CoA carboxylase alpha chain

3.3

No

BMEII0564

Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase (putA)

3.2

No

BMEII0079

Isochorismatase

3.2

No

BMEI0248

F0F1 ATP synthase subunit delta

3.1

No

BMEII0864

Oligopeptide transport ATP-binding protein AppF

3.1

No

BMEII1030

Putative lipoprotein

3.0

No

BMEII0084

Basic membrane protein A precursor

3.0

No

BMEII0083

Basic membrane protein A precursor

3.0

No

  1. Genes are listed in the order of fold-effect, with the fold change reflecting an increase in expression in the long-term samples in each case (see Additional file 8 for details on differential gene expression analysis; log2 (fold effect) values are displayed based on the analysis in Additional file 8). Gene descriptions are compiled from the Brucella Bioinformatics Portal (www.phidias.us)