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TableĀ 4 Candidate genes of interest in persistence based on upregulation in long-term (vs. short-term) samples

From: Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis

Locus tag Product name/description Log2 (fold change) Listed as virulence gene?
BMEII1062 (S)-2-hydroxy-acid oxidase subunit GlcE 4.8 No
BMEII1029 3-Deoxy-d-manno-octulosonic-acid transferase 4.3 No
BMEI1927 Enoyl-CoA hydratase 4.1 No
BMEII0089 Ribokinase (rbsK) 4.1 Yes
BMEII0086 Galactoside transport system permease MglC 4.0 No
BMEI1816 Sensory transduction protein kinase 4.0 No
BMEII0524 Hypothetical protein 3.7 No
BMEII0860 Oligopeptide transport system permease protein AppB 3.7 No
BMEII0862 Dihydrodipicolinate synthase 3.6 No
BMEI0234 Hypothetical cytosolic protein 3.5 No
BMEI1766 Sulfite reductase (ferredoxin; cysI) 3.4 Yes
BMEII0527 Exodeoxyribonuclease VII large subunit (xseA) 3.4 Yes
BMEII0526 Transcriptional regulatory protein, LysR family 3.4 No
BMEI0171 Ribosomal protein L11 methyltransferase 3.4 No
BMEI1926 Hydroxymethylglutaryl-CoA lyase 3.4 No
BMEI1817 ATP_dependent helicase HrpB 3.3 No
BMEI0173 Ycil-like protein 3.3 No
BMEI1925 Acetyl-CoA carboxylase alpha chain/propionyl-CoA carboxylase alpha chain 3.3 No
BMEII0564 Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase (putA) 3.2 No
BMEII0079 Isochorismatase 3.2 No
BMEI0248 F0F1 ATP synthase subunit delta 3.1 No
BMEII0864 Oligopeptide transport ATP-binding protein AppF 3.1 No
BMEII1030 Putative lipoprotein 3.0 No
BMEII0084 Basic membrane protein A precursor 3.0 No
BMEII0083 Basic membrane protein A precursor 3.0 No
  1. Genes are listed in the order of fold-effect, with the fold change reflecting an increase in expression in the long-term samples in each case (see Additional file 8 for details on differential gene expression analysis; log2 (fold effect) values are displayed based on the analysis in Additional file 8). Gene descriptions are compiled from the Brucella Bioinformatics Portal (