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Fig. 4 | BMC Molecular Biology

Fig. 4

From: Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939

Fig. 4

Sumoylation of p27kip1 promotes the proliferation of cholangiocarcinoma QBC939 cells. p27kip1 was found to be able to suppress the growth of QBC939 cells when it was artificially overexpressed in QBC939 cells (a). However, this effect can be partially rescued by overexpression of RanBP2 (a). Similar effect was observed when Crm-1 can partially rescue the anti-proliferative effect brought by p27kip1 overexpression (b). Moreover, EdU assay also verifies that both RanBP2 (c) and Crm-1 (d) can partially reverse the effect brought by overexpression of p27kip1 in QBC939 cells (**p < 0.01, ***p < 0.001)

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