Fig. 1
From: RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions
Schematic representation of SPI1 gene structure: Simplified scheme of the human SPI1 locus, indicating the two regulatory regions of SPI1: distal promoter (−17-kb URE) and proximal promoter. Binding sites for RUNX1 and SPI1 are shown by red and orange boxes, respectively. The red horizontal arrows in the URE and the proximal promoter indicate primers designed for methylation study