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Fig. 3 | BMC Molecular Biology

Fig. 3

From: Nucleophosmin: from structure and function to disease development

Fig. 3

a The crystal structure of the N-terminal oligomerization domain of NPM1 organized in a decamer, with two NPM1 pentameric rings stacked in a head-to-head fashion. Each NPM1 monomer is depicted in a different color. Structure derived from PDB data (PDB ID: 2P1B; [18]) visualized using Swiss PDB viewer. b Top view of a pentameric structure shown in a, showing the organization of monomers into a donut shaped ring. c Electrostatic potential map of a and b, showing an asymmetric distribution of charges, with negative charges (red) on the top surface of the pentamer and neutral (white) to slightly positive (blue) charges

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