Fig. 6
From: A potential role for protein palmitoylation and zDHHC16 in DNA damage response
zDHHC16 deficiency impaired DNA damage-induced Atm-p53 activation. a Western blot analysis showed reduced Atm phosphorylation at S1981 in zDHHC16−/− MEFs. Primary zDHHC16−/− MEFs were isolated from zDHHC16−/− mice and treated with 1 μM Dox for different periods of time as indicated. b Quantitation data on p-Atm. Asterisk denoted significant difference (p < 0.05) between control and 2BP treated cells. c Activation and induction of p53 and p21. Cells were treated the same as above