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Fig. 4 | BMC Molecular Biology

Fig. 4

From: Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

Fig. 4

Dgcr8Pax8Cre knockout mice have hydronephrotic and cystic kidneys. a and b PAS staining of the kidneys reveals alterations in all segments of the tubulus system. Beside a general reduction in kidney parenchyma (a), there are signs of hydronephrosis, cystic lesions in all parts of the nephron (b, glomerulocystic disease middle panel, tubular dilations/cysts right panel) and a marked activation of the Bowman epithelium (b, middle panel, see also Additional file 2: Figure S2) (a bar 2 mm; b bar = 100 µm, age of the mice 4–8 weeks)

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