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Fig. 1 | BMC Molecular Biology

Fig. 1

From: Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

Fig. 1

Dgcr8Pax8Cre knockout animals develop severe hypothyroidism. a and b Dgcr8 knockout mice are smaller and have a reduced body weight (control n = 11; knockout n = 9; age 4–5 weeks; p < 0.0001, error bars = SEM). c Dgcr8 knockout mice develop hypothyroidism as demonstrated by dramatically decreased fT4 levels in comparison to control littermates (control n = 5; knockout n = 4; age 4–8 weeks; p < 0.0001, error bars = SEM). d H&E staining of Dgcr8 knockout thyroid glands reveals a severely disorganized follicular architecture (top panel 5× magnification, bar 100 µm; bottom panel 20× magnification, bar 50 µm)

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