Fig. 9

Chk1 activation in Wt and Mut TLK1B expressing cells after treatment and recovery from HU a Mut TLK1B expressing cells show reduced phosphorylation of RPA at T21. During recovery from HU, phosphorylation of Chk1 at S317 and S345 persists for 8 h in cells expressing Mut TLK1B, in contrast to Wt expressing cells. b Treatment of cells with KU-55933 leads to a reduction of Chk1 phosphorylation in the Mut TLK1B expressing cells