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Table 4 Gene ontology analysis of Esrrb-dependent DY131-altered genes

From: Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells

Term (down-regulated genes)

Count

P value

GO:0042273 ~ ribosomal large subunit biogenesis

4

0.007

GO:0006297 ~ nucleotide-excision repair, DNA gap filling

4

0.032

GO:0006541 ~ glutamine metabolic process

4

0.042

GO:0009083 ~ branched chain family amino acid catabolic process

5

0.001

GO:0042274 ~ ribosomal small subunit biogenesis

5

0.001

GO:0009081 ~ branched chain family amino acid metabolic process

5

0.004

GO:0006904 ~ vesicle docking during exocytosis

5

0.016

GO:0048278 ~ vesicle docking

5

0.021

GO:0006958 ~ complement activation, classical pathway

5

0.031

GO:0022406 ~ membrane docking

5

0.038

GO:0002455 ~ humoral immune response mediated by circulating immunoglobulin

6

0.008

GO:0009060 ~ aerobic respiration

6

0.014

GO:0006635 ~ fatty acid beta-oxidation

7

0.001

GO:0009062 ~ fatty acid catabolic process

7

0.003

GO:0019395 ~ fatty acid oxidation

7

0.005

GO:0034440 ~ lipid oxidation

7

0.005

GO:0033559 ~ unsaturated fatty acid metabolic process

7

0.019

GO:0009064 ~ glutamine family amino acid metabolic process

7

0.020

GO:0019228 ~ regulation of action potential in neuron

7

0.024

GO:0006289 ~ nucleotide-excision repair

7

0.026

GO:0051591 ~ response to cAMP to cAMP

8

0.002

GO:0006800 ~ oxygen and reactive oxygen species metabolic process

8

0.021

GO:0001508 ~ regulation of action potential

8

0.023

GO:0009566 ~ fertilization

8

0.046

GO:0044242 ~ cellular lipid catabolic process

9

0.013

GO:0007160 ~ cell–matrix adhesion

9

0.032

GO:0060627 ~ regulation of vesicle-mediated transport

9

0.046

GO:0009063 ~ cellular amino acid catabolic process

10

0.002

GO:0045333 ~ cellular respiration

10

0.020

GO:0007568 ~ aging

10

0.040

GO:0016485 ~ protein processing

10

0.044

GO:0006364 ~ rRNA processing

11

0.005

GO:0016072 ~ rRNA metabolic process

11

0.007

GO:0006887 ~ exocytosis

11

0.022

GO:0009310 ~ amine catabolic process

12

0.000

GO:0008203 ~ cholesterol metabolic process

12

0.001

GO:0016125 ~ sterol metabolic process

12

0.003

GO:0042391 ~ regulation of membrane potential

12

0.024

GO:0015980 ~ energy derivation by oxidation of organic compounds

12

0.038

GO:0042254 ~ ribosome biogenesis

13

0.005

GO:0016053 ~ organic acid biosynthetic process

14

0.013

GO:0046394 ~ carboxylic acid biosynthetic process

14

0.013

GO:0022613 ~ ribonucleoprotein complex biogenesis

14

0.038

GO:0016042 ~ lipid catabolic process

15

0.013

GO:0006457 ~ protein folding

15

0.016

GO:0034470 ~ ncRNA processing

15

0.025

GO:0022900 ~ electron transport chain

16

0.000

GO:0032940 ~ secretion by cell

16

0.026

GO:0016054 ~ organic acid catabolic process

17

0.000

GO:0046395 ~ carboxylic acid catabolic process

17

0.000

GO:0034660 ~ ncRNA metabolic process

19

0.008

GO:0006631 ~ fatty acid metabolic process

21

0.000

GO:0046903 ~ secretion

22

0.014

GO:0006414 ~ translational elongation

25

0.000

GO:0008610 ~ lipid biosynthetic process

26

0.002

GO:0006091 ~ generation of precursor metabolites and energy

31

0.000

GO:0006412 ~ translation

38

0.000

GO:0016192 ~ vesicle-mediated transport

39

0.003

GO:0055114 ~ oxidation reduction

54

0.000

Term (up-regulated genes)

Count

P value

GO:0002220 ~ innate immune response activating cell surface receptor signaling pathway

2

0.045

GO:0048712 ~ negative regulation of astrocyte differentiation

2

0.045

GO:0000724 ~ double-strand break repair via homologous recombination

3

0.020

GO:0000725 ~ recombinational repair

3

0.020

GO:0045987 ~ positive regulation of smooth muscle contraction

4

0.001

GO:0045933 ~ positive regulation of muscle contraction

4

0.002

GO:0006940 ~ regulation of smooth muscle contraction

4

0.009

GO:0050768 ~ negative regulation of neurogenesis

4

0.015

GO:0010721 ~ negative regulation of cell development

4

0.018

GO:0006937 ~ regulation of muscle contraction

4

0.050

GO:0048704 ~ embryonic skeletal system morphogenesis

5

0.004

GO:0048706 ~ embryonic skeletal system development

5

0.012

GO:0031344 ~ regulation of cell projection organization

5

0.019

GO:0007411 ~ axon guidance

5

0.035

GO:0051258 ~ protein polymerization

6

0.000

GO:0043623 ~ cellular protein complex assembly

6

0.039

GO:0050767 ~ regulation of neurogenesis

6

0.042

GO:0048705 ~ skeletal system morphogenesis

7

0.002

GO:0060284 ~ regulation of cell development

7

0.031

GO:0007018 ~ microtubule-based movement

8

0.000

GO:0051960 ~ regulation of nervous system development

8

0.007

GO:0006916 ~ anti-apoptosis

8

0.010

GO:0007017 ~ microtubule-based process

8

0.027

GO:0001501 ~ skeletal system development

9

0.031

GO:0006917 ~ induction of apoptosis

9

0.031

GO:0012502 ~ induction of programmed cell death

9

0.032

GO:0045596 ~ negative regulation of cell differentiation

10

0.001

GO:0040008 ~ regulation of growth

10

0.017

GO:0043066 ~ negative regulation of apoptosis

10

0.021

GO:0043069 ~ negative regulation of programmed cell death

10

0.023

GO:0060548 ~ negative regulation of cell death

10

0.023

GO:0022403 ~ cell cycle phase

10

0.049

GO:0006928 ~ cell motion

12

0.021

GO:0042127 ~ regulation of cell proliferation

17

0.018

GO:0042981 ~ regulation of apoptosis

18

0.011

GO:0043067 ~ regulation of programmed cell death

18

0.012

GO:0010941 ~ regulation of cell death

18

0.012

GO:0006355 ~ regulation of transcription, DNA-dependent

29

0.047

GO:0051252 ~ regulation of RNA metabolic process

30

0.038

GO:0006350 ~ transcription

43

0.000

GO:0045449 ~ regulation of transcription

48

0.001