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Fig. 6 | BMC Molecular Biology

Fig. 6

From: Temperature-induced variation in gene expression burst size in metazoan cells

Fig. 6

Inference of the bursting kinetic parameters from the experimental distributions after 120 h incubation. a The curves are fitted by negative binomial distributions, where the curve shape is related to the burst frequency and the curve horizontal scale to the mean number of proteins per burst (see “Methods”). The burst size is the parameter mostly affected by temperature. b The comparison of the parameters inferred on different clones suggests that the burst frequency and size depend on the insertion site, but with a common temperature-dependence of the burst size (slope of the lines), probably indicative of the same reaction network involved in gene expression, and characterized by an effective activation energy EA = −60 ± 3 kcal/mol. The burst frequency exhibits a limited, clone-dependent increase. Values on vertical axes are expressed in natural logarithm

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