Figure 7

A model for SIRT6 interaction with MYH, APE1, and Rad9-Rad1-Hus1 to repair DNA damages on transcriptionally active chromatin and telomeres. The N- and C-terminal domains (in yellow) of MYH are connected with the interdomain connector (IDC, in green). SIRT6, APE1, and Rad9-Rad1-Hus1 bind overlapping but different sequence motifs on IDC region of MYH. The model suggests that SIRT6 in the complex with MYH, APE1, and 9-1-1 at sites of DNA damage may undergo auto mono-ADP-ribosylation leading to enhanced chromatin remodeling and optimal DNA repair efficiency.