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Figure 1 | BMC Molecular Biology

Figure 1

From: An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinoma

Figure 1

Ets1 is under repression by the Rb1 family. Mutation of Rb1 in primary cultures of mouse embryo fibroblasts (MEFs) led to significant (p < 0.05) induction of Ets1 mRNA, and Ets1 mRNA was further very significantly (p < 0.01) induced when all three closely related Rb1 family members (Rb1, Rbl1 and Rbl2) were mutated to generate triple knockout (TKO) MEFs. Real time PCR results normalized to actin mRNA are shown.

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