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Figure 8 | BMC Molecular Biology

Figure 8

From: Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex

Figure 8

Model of the role of the R 2 TP complex in the assembly of box C/D snoRNP. Snu13 binds early during the assembly, and Nop58 binds the snoRNA cotranscriptionally. The association of the R2TP complex and Hsp90 chaperone are important for the conformational change of Nop58, necessary for the binding of the Nop1 and Snu13 to form the mature snoRNP particle that will participate in rRNA maturation. In the absence of R2TP subunits, Nop58 is less stable, but shows higher affinity for RNA. In addition, in the absence of R2TP, snoRNAs and core snoRNP subunits mislocalize in the cell.

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