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Table 1 Proteins associated with the DNA-bound ERα

From: Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha

Protein

# of discrete peptides

% a.a. sequence identified

Effect on ERα-mediated transcription

References Cited

3-methyladenine DNA glycosylase (MPG)

3

14

Decrease

[40]

apurinic endonuclease-1 (APE1)

3

18

Gene specific

Curtis and Nardulli, Submitted

flap endonuclease-1 (FEN1)

3

13

Gene specific

[42]

high mobility group protein-2 (HMG-2)

2

13

Increase

[49, 50, 67]

nonmetastatic protein 23 homolog 1 (NM23-H1)

5

35

Decrease

[45]

proliferating cell nuclear antigen (PCNA)

9

57

Increases basal

[43]

protein disulfide isomerase (PDI)

7

19

Gene specific

[41]

pp32

5

19

Decrease

[39]

retinoblastoma associated protein 46 (RbAp46)

6

18

Gene specific

[47]

retinoblastoma associated protein 48 (RbAp48)

6

18

Decrease

[47]

rho-GDP dissociation inhibitor α (RhoGDIα)

7

57

Gene specific

[44]

superoxide dismutase 1 (SOD1)

9

86

Increase

[46]

template activating factor 1β (TAF-Iβ)

16

38

Decrease

[38]

thioredoxin (Trx)

4

46

Gene specific

Rao and Nardulli, In Preparation

thioredoxin reductase (TrxR)

14

54

Gene specific

Rao and Nardulli, In Preparation

  1. Selected ERα-associated proteins were characterized. The effect of each protein on ERα-mediated transcription was analyzed by transient transfection and/or RNA interference assays.