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Table 1 Proteins associated with the DNA-bound ERα

From: Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha

Protein # of discrete peptides % a.a. sequence identified Effect on ERα-mediated transcription References Cited
3-methyladenine DNA glycosylase (MPG) 3 14 Decrease [40]
apurinic endonuclease-1 (APE1) 3 18 Gene specific Curtis and Nardulli, Submitted
flap endonuclease-1 (FEN1) 3 13 Gene specific [42]
high mobility group protein-2 (HMG-2) 2 13 Increase [49, 50, 67]
nonmetastatic protein 23 homolog 1 (NM23-H1) 5 35 Decrease [45]
proliferating cell nuclear antigen (PCNA) 9 57 Increases basal [43]
protein disulfide isomerase (PDI) 7 19 Gene specific [41]
pp32 5 19 Decrease [39]
retinoblastoma associated protein 46 (RbAp46) 6 18 Gene specific [47]
retinoblastoma associated protein 48 (RbAp48) 6 18 Decrease [47]
rho-GDP dissociation inhibitor α (RhoGDIα) 7 57 Gene specific [44]
superoxide dismutase 1 (SOD1) 9 86 Increase [46]
template activating factor 1β (TAF-Iβ) 16 38 Decrease [38]
thioredoxin (Trx) 4 46 Gene specific Rao and Nardulli, In Preparation
thioredoxin reductase (TrxR) 14 54 Gene specific Rao and Nardulli, In Preparation
  1. Selected ERα-associated proteins were characterized. The effect of each protein on ERα-mediated transcription was analyzed by transient transfection and/or RNA interference assays.