Identification of SBR, a novel RNA-binding domains proximal to NHR2. A. In silico analysis of the MTG8 protein sequence with BindN and RNAbindR software predicts RNA-binding residues in a region between a.a. 316 and a.a. 333 (top). This sequence is part of a short basic region (SBR) highly conserved across the three human MTGs and across different species (bottom). B. Deletion of MTG8 N-terminus, containing the SBR (MTG8Δ3), abrogates Zinc-independent poly(U)-binding; further deletion of MTG8 C-terminus, containing the Zinc Finger (ZF) domains (MTG8Δ4), abrogates also Zinc-dependent poly(U)-binding.