TY - JOUR AU - Rossetti, Stefano AU - van Unen, Leontine AU - Sacchi, Nicoletta AU - Hoogeveen, Andre T. PY - 2008 DA - 2008/10/24 TI - Novel RNA-binding properties of the MTG chromatin regulatory proteins JO - BMC Molecular Biology SP - 93 VL - 9 IS - 1 AB - The myeloid translocation gene (MTG) proteins are non-DNA-binding transcriptional regulators capable of interacting with chromatin modifying proteins. As a consequence of leukemia-associated chromosomal translocations, two of the MTG proteins, MTG8 and MTG16, are fused to the DNA-binding domain of AML1, a transcriptional activator crucial for hematopoiesis. The AML1-MTG fusion proteins, as the wild type MTGs, display four conserved homology regions (NHR1-4) related to the Drosophila nervy protein. Structural protein analyses led us to test the hypothesis that specific MTG domains may mediate RNA binding. SN - 1471-2199 UR - https://doi.org/10.1186/1471-2199-9-93 DO - 10.1186/1471-2199-9-93 ID - Rossetti2008 ER -