Table 2 Transcription factor family members
From: New insights into SRY regulation through identification of 5' conserved sequences
| Family | Transcription factors |
|---|---|
| BRNF | Brn POU domain factors |
| BRN2/3/4/5 | |
| OCT1 | Octamer binding protein |
| OCT1/2/3 | |
| HOXF | Factors with moderate activity to homeodomain consensus sequence |
| Barx2, CRX, GSC, Gsh-1/2, HOX1, HOXA9, HOXB9, HOXC13, NANOG, OTX2, PCE1, PHOX2a/2b, PTX1 pituitary homeobox. | |
| PARF | PAR/bZIP family |
| DBP Albumin D-box binding protein, HLF hepatic leukemia factor, TEF Thyrotrophic embryonic factor, VBP PAR-type chicken vitellogenin promoter binding protein. | |
| FKHD | Fork head domain factors |
| FHXA/B, FKHRL1 (FOXO), FREAC2/3/4/7 fork head related activators (FOXF2, FOXC1, FOXD1, FOXL1), HFH1/2/3/8 (FOXQ1, FOXD3, FOXI1, Freac-6. FXF1), HNF3B (FOXA2), IlF1 (FOXK2), XFD1/2/3. | |
| GATA | GATA binding factors |
| GATA, GATA1/2/3. | |
| CREB | Camp-responsive element binding proteins |
| ATF, ATF2/6 activation transcription factors, c-Jun/ATF2 heterodimers, CREB, CREB1/2, CREB2/cJun, E4BP4, TAX/CREB complex, XBP1 X-box-binding protein. | |
| CDXF | Vertebrate caudal related homeodomain Protein |
| CDX1/2 Intestine specific homeodomain factor and mammalian caudal related intestinal TF. | |
| SRFF | Serum response element binding factor |
| SRF.01/02/03 | |
| MEF2 | Myocyte-specific enhancer binding Factor |
| MEF2, RSRFC4 related to serum response factor, SL1 member of RSRF | |
| ETSF | Human and murine ETS1 factors |
| c-Ets-1/2(p54), ELF-2(NERF1a), ELK1, FLI, GABP GA binding protein, GABPB1 GA repeat binding protein beta 1, NRF2 nuclear respiratory factor 2, PDEF Prostate-derived Ets factor, PEA3 polyomavirus enhancer A binding protein 3, ETV4, PU1, SPI1, SpiB. | |
| HNF1 | Hepatic nuclear factor 1 |
| HNF1 | |
| SORY | SOX/SRY-sex/testis determining and related HMG box factors |
| HBP1, HMGA1/2, HMGIY, SOX5/9, SRY. | |
| NKXH | NKX homeodomain factors |
| Hmx2/Nkx5-2 homeodomain transcription factor, NKX31 prostate-specific homeodomain protein, TTF1 thyroid transcription factor | |
| LHXF | Lim homeodomain factors |
| LHX3 and LMXB1 | |
| MYT1 | MYT1 C2HC zinc finger protein |
| MyT1 myelin transcription factor, and MyT1L. | |
| PLZF | C2H2 zinc finger protein |
| PLZF promyelocytic leukemia zinc finger (TF with 9 Kruppel-like zinc fingers) | |
| NFKB | Nuclear factor kappa B/c-rel |
| NF-kappaB (p50 and p65), HIVEP1; ZAS Domain TF human immunodeficiency virus type 1 enhancer-binding protein-1 (HIVEP1), major histocompatibility complex-binding protein-1 (MBP-1), positive regulatory domain II-binding factor (PRDII-BF1) | |
| EVI1 | Myleoid transforming protein |
| EVI1 ecotropic viral integration site 1 encoded factor, amino-terminal zinc finger domain. MEL1 (MDS1/EVI1-like gene 1) DNA-binding domain 1. | |
| TBPF | TATA-binding protein factors |
| ATATA avian C-type LTR TAT box, LTATA Lentivirus LTR TAT box, MTATA muscle TATA box, TATA cellular and viral TATA box elements, and Mammalian C-type LTR TATA box. | |
| HOXC | HOX – PBX complexes |
| HOX/PBX binding sites, PBX1, PBX-HOXA9 binding site. | |
| GFI1 | Growth factor independence transcriptional Repressor |
| GFI1.01/02, GFI1B.01. | |
| PITI | GHF-1 pituitary specific pou domain TF |
| Pit1, GHF1. | |
| OCTP | OCT1 binding factor (POU-specific domain) |
| OCT1P Octamer-binding factor 1, POU-specific domain) | |
| RORA | v-ERB and RAR-related orphan receptor alpha |
| REV-ERBA orphan nuclear receptor rev-erb alpha (NR1D1), RORA/RORA1/2 RAR-related orphan receptor alpha/1/2, RORGAMMA RAR-related orphan receptor gamma, VERBA viral homolog of thyroid hormone receptor alpha1 | |
| HAML | Human acute myelogenous leukemia factors |
| AML1/CBFA2 Runt domain binding site, AML3 runt-related transcription factor 2/CBFA1 | |
| RBPF | RBPJ kappa |
| Mammalian transcriptional repressor RBP-Jkappa/CBF1 | |
| IRFF | Interferon regulatory factors |
| IRF1/2/3/4(NF-EM5, PIP, LSIRF, ICSAT)/7, ISRE interferone stimulated response element. | |
| PAX6 | PAX-4/PAX-6 paired domain binding sites |
| PAX4 and PAX6 paired domain binding site | |
| MZF1 | Myeloid zinc finger 1 factors |
| MZF1 | |
| GZF1 | GDNF-inducible zinc finger gene 1 |
| GZF1 (ZNF336) | |
| ZFHX | Two-handed zinc finger homeodomain transcription factors |
| AREB6 (Atp1a1 regulatory element binding factor 6), deltaEF1 (Delta-crystallin enhancer binding factor, transcription factor 8, zinc finger homeobox 1a), SIP1 (Smad-interacting protein) | |
| PLAG | Pleomorphic adenoma gene |
| (PLAG) 1, a developmentally regulated C2H2 zinc finger protein | |
| MOKF | Mouse Kruppel like factors |
| MOK2.01/02 Ribonucleoprotein associated zinc finger protein MOK-2 | |
| HOMF | Homeodomain transcription factors |
| DLX1/2/5, Distal-less 3, EN1 homeobox protein engrailed, HHEX, MSX1/2, NOBOX, S8. | |
| RBIT | Regulator of B-Cell IgH transcription |
| Bright, B cell regulator of IgH transcription | |
| SATB | Special AT-rich sequence binding |
| Protein SATB1 | |
| CLOX | CLOX and CLOX homology (CDP) factors |
| CDP cut-like homeodomain protein, transcriptional repressor CDP, CDPCR3, CDPCR3HD, CLOX, CUT2. |