New insights into SRY regulation through identification of 5' conserved sequences

BMC Molecular Biology

Table 1 Transcription factor binding sites found in SRY 5' regions

Family	Reg. A	Reg. B	Reg. C	Reg. D	TOTAL
BRNF			b/g/p (×2)	b/g/h (×2) b/g/p (×2)	18
OCT1			b/g/p (×2)	b/g/p (×2) b/g/h (×2)	18
HOXF	b/g/h	b/g/h	b/g/p/h	b/g/h	13
PARF			b/g/p	b/g/p (×3)	12
FKHD			b/g/p	b/g/p b/g/h/p	10
GATA	b/g/h (×2)		b/g/p		9
CREB			b/g/p	b/g/p (×2)	9
CDXF				b/g/h/p (×2)	8
SRFF		b/g/h		b/g/h/p	7
MEF2		b/g/h		g/h/p	6
ETSF			b/g/h, b/g/p		6
HNF1			b/g/p	b/g/h	6
SORY			b/g/p	g/h/p	6
NKXH				b/g/h b/g/p	6
LHXF			b/g/p/h		4
MYT1				b/g/h/p	4
PLZF				b/g/h/p	4
NFKB				b/g/h/p	4
EVI1	b/g/h				3
TBPF	b/g/h				3
HOXC	b/g/h				3
GFI1	b/g/h				3
PITI	b/g/h				3
OCTP	b/g/h				3
RORA		b/g/h			3
HAML		b/g/h			3
RBPF		b/g/h			3
IRFF			b/g/p		3
PAX6			b/g/p		3
MZF1			b/g/p		3
GZF1			b/g/h		3
ZFHX			b/g/p		3
PLAG			b/g/p		3
MOKF				b/g/h	3
HOMF				b/g/h	3
RBIT				b/g/h	3
SATB				b/g/p	3
CLOX				b/g/h	3
TOTAL	27	18	62	103	210

Only sites conserved between 3 or more species are shown. Sites conserved between 4 species are marked in bold. Numbers in parentheses indicate the number of times each binding site was found in the same region. Data are sorted in order of most common to least common transcription factor binding sites. Bovine (b), goat (g), human (h), pig (p), mouse (m).

ISSN: 1471-2199