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Table 2 Functional classification analysis of genes changed significantly after 5 days of mutant huntingtin expression

From: Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

Functional Classification with genes that showed an increased expression after 5 days Functional Classification with genes that showed a decreased expression after 5 days
Ontology Term # genes P value Ontology Term # genes P value
BP Negative regulation of dendrite
morphogenesis
3 0,004904 BP Regulation of heart contraction 7 0,000823
  Negative regulation of fibroblast proliferation 3 0,004904   Isoprenoid biosynthesis 4 0,003744
  Cell adhesion 16 0,009781   Galactose metabolism 3 0,005365
  Response to DNA damage stimulus 8 0,011782   Angiogenesis 9 0,007585
  Positive regulation of caspase activity 4 0,014506   Response to stress 40 0,007784
  Positive regulation of hydrolase activity 4 0,019419   Neg. regulation of transcription
from RNA polII promoter
8 0,007866
  Apoptotic nuclear changes 3 0,021186   Cell motility 18 0,008263
  Mitochondrial membrane organization
and biogenesis
3 0,021186   Pos. regulation of transcription
from RNA polII promoter
10 0,010333
  Metal ion homeostasis 8 0,021801   Actin cytoskeleton organization
and biogenesis
10 0,011951
  Carbohydrate biosynthesis 6 0,023170   Blood vessel morphogenesis 9 0,015755
  Biopolymer metabolism 38 0,024409   Cholesterol metabolism 7 0,016064
  Fibroblast proliferation 3 0,026721   Glucose catabolism 6 0,022220
  Protein oligomerization 4 0,035235   Histogenesis and organogenesis 3 0,024619
CC Antioxidant activity 5 0,015651   Regulation of neuronal synaptic
plasticity
4 0,029030
  Stress fiber 3 0,017610   Somitogenesis 3 0,033500
  Cytoplasmic membrane-bound vesicle 10 0,019229   Synaptic transmission, dopaminergic 3 0,033500
  Nuclear chromosome 4 0,030424   cAMP metabolism 4 0,039722
MF Electron transporter activity 11 0,001023   Neurotransmitter transport 6 0,046079
  Chemokine receptor binding 6 0,001069 CC Endosome membrane 3 0,008890
  Metalloendopeptidase inhibitor activity 3 0,007766   Actin cytoskeleton 9 0,033881
  Selenium binding 4 0,008247   Cell projection 13 0,033985
  Protease inhibitor activity 7 0,013043   Cytoplasmic membrane-bound
vesicle
12 0,038151
  GTPase activity 8 0,013763   Mitochondrion 24 0,043218
  Guanyl nucleotide binding 9 0,040251   Spindle 4 0,048198
  Zinc ion binding 17 0,041022 MF Double-stranded DNA binding 7 0,001838
244 genes
included in
analysis
     SH3/SH2 adaptor activity 5 0,004637
      Oxidoreductase activity, acting
on the CH-CH group of donors
6 0,004683
      Cell cycle regulator 4 0,005046
      Epidermal growth factor
receptor binding
3 0,023409
      Protein phosphorylated amino
acid binding
3 0,023409
      Actin binding 10 0,026446
      Monoamine transporter activity 3 0,031878
      SNAP receptor activity 3 0,031878
      Carbohydrate kinase activity 4 0,031902
      Transcriptional activator activity 11 0,045287
     331 genes
included in
analysis
   
  1. BP: Biological Process.
  2. CC: Cellular Component.
  3. MF: Molecular Function