Table 2 Functional classification analysis of genes changed significantly after 5 days of mutant huntingtin expression

BP

Negative regulation of dendrite

morphogenesis

3

0,004904

BP

Regulation of heart contraction

7

0,000823

Negative regulation of fibroblast proliferation

3

0,004904

Isoprenoid biosynthesis

4

0,003744

Cell adhesion

16

0,009781

Galactose metabolism

3

0,005365

Response to DNA damage stimulus

8

0,011782

Angiogenesis

9

0,007585

Positive regulation of caspase activity

4

0,014506

Response to stress

40

0,007784

Positive regulation of hydrolase activity

4

0,019419

Neg. regulation of transcription

from RNA polII promoter

8

0,007866

Apoptotic nuclear changes

3

0,021186

Cell motility

18

0,008263

Mitochondrial membrane organization

and biogenesis

3

0,021186

Pos. regulation of transcription

from RNA polII promoter

10

0,010333

Metal ion homeostasis

8

0,021801

Actin cytoskeleton organization

and biogenesis

10

0,011951

Carbohydrate biosynthesis

6

0,023170

Blood vessel morphogenesis

9

0,015755

Biopolymer metabolism

38

0,024409

Cholesterol metabolism

7

0,016064

Fibroblast proliferation

3

0,026721

Glucose catabolism

6

0,022220

Protein oligomerization

4

0,035235

Histogenesis and organogenesis

3

0,024619

CC

Antioxidant activity

5

0,015651

Regulation of neuronal synaptic

plasticity

4

0,029030

Stress fiber

3

0,017610

Somitogenesis

3

0,033500

Cytoplasmic membrane-bound vesicle

10

0,019229

Synaptic transmission, dopaminergic

3

0,033500

Nuclear chromosome

4

0,030424

cAMP metabolism

4

0,039722

MF

Electron transporter activity

11

0,001023

Neurotransmitter transport

6

0,046079

Chemokine receptor binding

6

0,001069

CC

Endosome membrane

3

0,008890

Metalloendopeptidase inhibitor activity

3

0,007766

Actin cytoskeleton

9

0,033881

Selenium binding

4

0,008247

Cell projection

13

0,033985

Protease inhibitor activity

7

0,013043

Cytoplasmic membrane-bound

vesicle

12

0,038151

GTPase activity

8

0,013763

Mitochondrion

24

0,043218

Guanyl nucleotide binding

9

0,040251

Spindle

4

0,048198

Zinc ion binding

17

0,041022

MF

Double-stranded DNA binding

7

0,001838

244 genes

included in

analysis

SH3/SH2 adaptor activity

5

0,004637

Oxidoreductase activity, acting

on the CH-CH group of donors

6

0,004683

Cell cycle regulator

4

0,005046

Epidermal growth factor

receptor binding

3

0,023409

Protein phosphorylated amino

acid binding

3

0,023409

Actin binding

10

0,026446

Monoamine transporter activity

3

0,031878

SNAP receptor activity

3

0,031878

Carbohydrate kinase activity

4

0,031902

Transcriptional activator activity

11

0,045287

331 genes

included in

analysis