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Table 1 Functional grouping of genes that show a significant change in expression between mutant and wild-type cells (Q74-Q23) after 1 day of induction
| Genes up after 1 day of mutant huntingtin expression | Genes down after 1 day of mutant huntingtin expression | ||||||
|---|---|---|---|---|---|---|---|
| Gene | Accession # | Gene | Accession # | Gene | Accession # | Gene | Accession # |
| Apoptosis-related proteins | Cell cycle and growth factors | ||||||
| Gstp1 | XM_579338 | Tnfaip8* | XM_225940 | Igf2 | NM_031511 | Cdc14a* | XM_227618 |
| Cell cycle and growth factors | Smpd3 | NM_053605 | |||||
| Tgfa | NM_012671 | Cell signalling | |||||
| Cell signalling | Arl6* | XM_344009 | Plxnb1* | XM_236640 | |||
| Flrt2* | XM_234361 | Rgs14 | NM_053764 | Calm1 | XM_579543 | Panx2 | XM_579735 |
| Rasl11b | NM_001002830 | GAP1(sim) | XM_227132 | Chromatin remodeling – transcription | |||
| Rgs2 | NM_053453 | Smad4 | NM_019275 | Cbx6* | XM_576309 | ||
| Chromatin remodeling – transcription | Chc1l | NM_199084 | Ttf2* | XM_215670 | |||
| Hoxb13* | XM_220905 | Vax2 | NM_022637 | Prickle1 | XM_235609 | Dnajb6* | XM_342607 |
| LOC362865 | XM_343194 | LOC368057 | XM_347220 | Mdc1 | XM_227971 | ||
| Npas1* | XM_238770 | Dclre1b* | XM_227537 | Cytoskeleton – cellular matrix | |||
| Hoxb9* | XM_220887 | Epb4.1l4a* | XM_226060 | RGD1310323 | NM_001008348 | ||
| Cytoskeleton – cellular matrix | Add3 | NM_031552 | Cilp* | XM_236348 | |||
| Mybph | NM_031813 | Plekhh1* | XM_234332 | ||||
| Electron transport – mitochondrion | Electron transport – mitochondrion | ||||||
| LOC293949 | XM_215248 | Dhrs4 | NM_153315 | ||||
| Ion channels – receptors | Ion channels – receptors | ||||||
| Ms4a8b* | XM_342026 | Olr677* | NM_001001062 | Boc* | XM_340986 | Ms4a11* | XM_342028 |
| Ccr7 | NM_199489 | Olr1340* | XM_236174 | LOC501049 | XM_576464 | Olfml2b* | XM_222868 |
| Trpv6 | NM_053686 | Olr1597* | NM_001000911 | Trpv2 | NM_017207 | ||
| Olr29* | NM_001000691 | Ttyh3* | XM_221962 | Oxidative stress | |||
| Olr552* | NM_001001055 | Il17rb* | XM_224604 | Prdx6 | NM_053576 | ||
| Olr1751* | NM_001000492 | RNA processing and ribosomal | |||||
| Oxidative stress | Mrps15 | NM_001007653 | Rps16 | XM_341815 | |||
| Blvra | NM_053850 | Indo | NM_023973 | Vesicle trafficking | |||
| RNA processing and ribosomal | Sec24d* | XM_227663 | Sytl4 | NM_080410 | |||
| Ear11 | NM_138902 | Rps24 | NM_031112 | Other | |||
| Trim21* | XM_219011 | Ptrh1* | XM_342416 | Tekt2* | XM_575908 | LOC500847 | XM_576239 |
| Vesicle trafficking | Chst1* | XM_575178 | Adhfe1* | XM_342794 | |||
| Eml1* | XM_343109 | Lypla2 | NM_031342 | Pigl | NM_138901 | ||
| Other | LOC365544 | XM_345087 | Herpud1 | NM_053523 | |||
| LOC499985 | XM_575339 | Atad2* | XM_235326 | LOC367880 | XM_579653 | ||
| Smyd2 | XM_213972 | LOC498435 | XM_573687 | ||||
| Tpbg | NM_031807 | Smpx | NM_053395 | ||||
| C4.4a | NM_021759 | Mocs1* | XM_236911 | ||||
| Abhd1 | NM_001008520 | Serpinf1 | NM_177927 | ||||
| Ppic | NM_001004215 | Smp2a | NM_012695 | ||||
| Aak1* | XM_232172 | Rhcg | NM_183053 | ||||
| Prss8 | NM_138836 | Prlph | NM_021580 | ||||
| LOC367332 | XM_346086 | Xylt1 | XM_341912 | ||||
| Cyp4a10 | NM_153307 | ||||||
