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Table 1 Functional grouping of genes that show a significant change in expression between mutant and wild-type cells (Q74-Q23) after 1 day of induction

From: Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

Genes up after 1 day of mutant huntingtin expression

Genes down after 1 day of mutant huntingtin expression

Gene

Accession #

Gene

Accession #

Gene

Accession #

Gene

Accession #

Apoptosis-related proteins

Cell cycle and growth factors

Gstp1

XM_579338

Tnfaip8*

XM_225940

Igf2

NM_031511

Cdc14a*

XM_227618

Cell cycle and growth factors

Smpd3

NM_053605

  

Tgfa

NM_012671

  

Cell signalling

Cell signalling

Arl6*

XM_344009

Plxnb1*

XM_236640

Flrt2*

XM_234361

Rgs14

NM_053764

Calm1

XM_579543

Panx2

XM_579735

Rasl11b

NM_001002830

GAP1(sim)

XM_227132

Chromatin remodeling – transcription

Rgs2

NM_053453

  

Smad4

NM_019275

Cbx6*

XM_576309

Chromatin remodeling – transcription

Chc1l

NM_199084

Ttf2*

XM_215670

Hoxb13*

XM_220905

Vax2

NM_022637

Prickle1

XM_235609

Dnajb6*

XM_342607

LOC362865

XM_343194

LOC368057

XM_347220

Mdc1

XM_227971

  

Npas1*

XM_238770

Dclre1b*

XM_227537

Cytoskeleton – cellular matrix

Hoxb9*

XM_220887

  

Epb4.1l4a*

XM_226060

RGD1310323

NM_001008348

Cytoskeleton – cellular matrix

Add3

NM_031552

Cilp*

XM_236348

Mybph

NM_031813

  

Plekhh1*

XM_234332

  

Electron transport – mitochondrion

Electron transport – mitochondrion

LOC293949

XM_215248

  

Dhrs4

NM_153315

  

Ion channels – receptors

Ion channels – receptors

Ms4a8b*

XM_342026

Olr677*

NM_001001062

Boc*

XM_340986

Ms4a11*

XM_342028

Ccr7

NM_199489

Olr1340*

XM_236174

LOC501049

XM_576464

Olfml2b*

XM_222868

Trpv6

NM_053686

Olr1597*

NM_001000911

Trpv2

NM_017207

  

Olr29*

NM_001000691

Ttyh3*

XM_221962

Oxidative stress

Olr552*

NM_001001055

Il17rb*

XM_224604

Prdx6

NM_053576

  

Olr1751*

NM_001000492

  

RNA processing and ribosomal

Oxidative stress

Mrps15

NM_001007653

Rps16

XM_341815

Blvra

NM_053850

Indo

NM_023973

Vesicle trafficking

RNA processing and ribosomal

Sec24d*

XM_227663

Sytl4

NM_080410

Ear11

NM_138902

Rps24

NM_031112

Other

Trim21*

XM_219011

Ptrh1*

XM_342416

Tekt2*

XM_575908

LOC500847

XM_576239

Vesicle trafficking

Chst1*

XM_575178

Adhfe1*

XM_342794

Eml1*

XM_343109

  

Lypla2

NM_031342

Pigl

NM_138901

Other

LOC365544

XM_345087

Herpud1

NM_053523

LOC499985

XM_575339

Atad2*

XM_235326

LOC367880

XM_579653

  

Smyd2

XM_213972

LOC498435

XM_573687

    

Tpbg

NM_031807

Smpx

NM_053395

    

C4.4a

NM_021759

Mocs1*

XM_236911

    

Abhd1

NM_001008520

Serpinf1

NM_177927

    

Ppic

NM_001004215

Smp2a

NM_012695

    

Aak1*

XM_232172

Rhcg

NM_183053

    

Prss8

NM_138836

Prlph

NM_021580

    

LOC367332

XM_346086

Xylt1

XM_341912

    

Cyp4a10

NM_153307

      
  1. * predicted