From: Pioglitazone retrieves hepatic antioxidant DNA repair in a mice model of high fat diet
Group | Chow diet (n = 5) | High fat diet (n = 5) | High fat diet + PioG (n = 5) | P |
---|---|---|---|---|
Initial BW (gm) | 21.1 ± 0.3 | 21.6 ± 0.4 | 20.8 ± 0.5 | 0.538 |
Final BW (gm) | 24.8 ± 0.9 | 26.0 ± 0.9 | 27.6 ± 0.7 | 0.088 |
BW gain (gm) | 3.7 ± 0.7 | 4.4 ± 0.8 | 5.0 ± 0.5 | 0.025 |
Blood glucose (mg/dl) | 125.0 ± 8.0 | 169.2 ± 4.2 | 147.6 ± 7.2 | 0.011 |
Cholesterol (mg/dl) | 59.5 ± 10.4 | 159.7 ± 37.1 | 151.6 ± 14.2 | 0.008 |
Triglyceride (mg/dl) | 71.9 ± 17.1 | 102.8 ± 27.6 | 95.9 ± 13.0 | 0.355 |
ALT (IU/L) | 14.8 ± 5.5 | 13.0 ± 5.9 | 27.7 ± 13.6 | 0.691 |
Hepatic TG (mg/g protein) | 72.0 ± 19.9 | 177.5 ± 61.4 | 153.6 ± 60.9 | 0.023 |
MDA (nmol/mg protein) | 5.9 ± 1.0 | 9.7 ± 0.8 | 5.5 ± 0.3 | 0.008 |