Brf1 and Brf2 have a high sequence similarity to the codon determinant region of c-myc. (A) Schematic representation of Brf1, Brf2 and c-myc. Structural features are indicated. Location of nucleotide sequences aligned (red text) in lower panel are indicated by red brackets. (B) Sequence alignment of the codon determinant region of c-myc, Brf1 and Brf2. Identical amino acids in all three sequences are depicted in yellow. Sequences identical in two of the three sequences are highlighted in blue. Consensus sequence is indicated.