Figure 4
From: Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene
A. Schematic summary of results. The human BCL2L11(BIM) locus is shown aligned with relevant ESTs and with the RT-PCR and 5'RACE products. For simplicity the alias BIM is used in the figure instead of the approved gene symbol BCL2L11. The transcript originating in the BIM promoter 1 region defines a novel BIM exon comprising sequences covered by Genbank ESTs and spliced onto the first coding exon of BIM. B. BIM-P1 sequences can drive transcription of a luciferase reporter when transiently transfected in HEK293 cells. pBIM-P1 constructs (-1918 relatively to the HEK293 transcript initiation site) demonstrate that the sequence can drive transcription of the reporter in an orientation-independent manner. *p < 0.01, Anova: single factor.