Figure 8From: A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiationA mutated form of WT1 (WT1 R394W) that causes retention of Müllerian ducts in humans fails to synergize with GATA4. A. HeLa cells were co-transfected with the mouse -180 bp Amh promoter and either an empty expression vector (control) or expression vectors for GATA4 (100 ng), WT1(-KTS) wild-type (500 ng) or WT1(-KTS) R394W DDS mutant (500 ng), used alone or in combination as indicated. All promoter activities are reported as fold activation over control ± S.E.M. Like letters indicate no statistically significant difference between groups (P > 0.05).Back to article page