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Figure 8 | BMC Molecular Biology

Figure 8

From: A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Figure 8

A mutated form of WT1 (WT1 R394W) that causes retention of Müllerian ducts in humans fails to synergize with GATA4. A. HeLa cells were co-transfected with the mouse -180 bp Amh promoter and either an empty expression vector (control) or expression vectors for GATA4 (100 ng), WT1(-KTS) wild-type (500 ng) or WT1(-KTS) R394W DDS mutant (500 ng), used alone or in combination as indicated. All promoter activities are reported as fold activation over control ± S.E.M. Like letters indicate no statistically significant difference between groups (P > 0.05).

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