TY - JOUR AU - Rath, Bandita AU - Pandey, Ravi S. AU - Debata, Priya R. AU - Maruyama, Naoki AU - Supakar, Prakash C. PY - 2008 DA - 2008/04/29 TI - Molecular characterization of senescence marker protein-30 gene promoter: Identification of repressor elements and functional nuclear factor binding sites JO - BMC Molecular Biology SP - 43 VL - 9 IS - 1 AB - Senescence marker protein-30 (SMP30), whose expression declines during aging in rat liver, has been proposed as an important aging marker. Besides apoptosis, SMP30 also protects cells against various other injuries by enhancement of membrane calcium-pump activity. The mechanism of this differential gene expression mechanism is not known. DNA-protein interactions, mutation analysis and luciferase reporter assay studies have been performed to elucidate the mechanism of transcriptional regulation of SMP30 gene. SN - 1471-2199 UR - https://doi.org/10.1186/1471-2199-9-43 DO - 10.1186/1471-2199-9-43 ID - Rath2008 ER -