Figure 1

uri genomic region, mutant alleles and protein domain architecture. A. The uri genomic region adapted from FlyBase. The uri 3' UTR overlaps with the 3' UTR of CG12252, encoded on the opposite strand. The position of the P{GSV6}GS16344 insertion in uri¹ is shown, as is the extent of the deletion in uri^110b. B. Schematic diagram showing the similarity in domain architecture between Drosophila Uri, human URI and C. elegans URI-1 proteins. Wavy box – prefoldin domain; Striped box – coiled coil; Stippled box – repeat region; grey box – URI box (C-terminal conserved motif); asterisk – predicted PP1c binding site; inverted triangles – predicted NLS; bracket – region of human URI present in the RMP-D2 truncated protein. Truncated proteins that could be encoded by the transcript remaining in uri^110bare indicated.