Skip to main content
Figure 1 | BMC Molecular Biology

Figure 1

From: Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue

Figure 1

DBD amino acid comparison. A. Alignment of the amino acid sequence of NR2E DNA-binding domains from NR2E1 and NR2E3 subclasses. The sequences were aligned as described in Methods. Potential amino acid residues that might make DNA base contacts (B), phosphate contacts (P), and dimerization contracts (D) were inferred from structural studies on RXR/RAR heterodimer recognition of DR1 sites and similar studies [35, 36]. B. Comparison of P box sequences of NR2E1 and NR2E3 subclasses to other C. elegans nuclear receptors examined in this study and other representative nuclear receptors from humans. Species abbreviations: Ce, Caenorhabditis elegans; Cb, Caenorhabditis briggsae; Dm, Drosophila melanogaster; Hs, Homo sapiens; Mm, Mus musculus.

Back to article page

BMC Molecular Biology

ISSN: 1471-2199

Contact us