Figure 5

Potential roles of CSE1 and CSE2 for transcriptional regulation of the Peg3 and Usp29. Arrows indicate the transcriptional directions of Peg3 and Usp29, and their size and thickness represent the transcriptional strength of Peg3 and Usp29. Smaller rectangles indicate seven individual sections within CSE1 that have been individually mutated. The mutated section is marked with a black rectangle. Open and black ovals indicate intact and mutated YY1 binding sites, respectively. In the Peg3 direction (A), the YY1 binding sites (CSE2) function as activators, whereas CSE1 acts as a repressor for the Peg3 transcription. In the Usp29 direction (B), the functional contribution of the YY1 binding sites is unknown, but CSE1 most likely plays a repressor role for Usp29 transcription.