TY - JOUR AU - Weber, Jan M. AU - Irlbacher, Horst AU - Ehrenhofer-Murray, Ann E. PY - 2008 DA - 2008/11/06 TI - Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase JO - BMC Molecular Biology SP - 100 VL - 9 IS - 1 AB - Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1. SN - 1471-2199 UR - https://doi.org/10.1186/1471-2199-9-100 DO - 10.1186/1471-2199-9-100 ID - Weber2008 ER -