Figure 5
From: ADAM15 gene structure and differential alternative exon use in human tissues
The cDNA sequence and amino acid translation of human ADAM15 alternatively spliced cytosolic tail-encoding region. The horizontal lines indicate the exon/intron boundaries. The a and b forms of the exon 20 differ by three nucleotides shown in bold. The adenylation signal is shown in bold. The start of the exon 21b-unique region is indicated with 21b. The upper translation corresponds to the mRNA variants containing the exon 19 and the lower translation corresponds to the alternative variants without the exon 19. The last amino acid encoded by the exons 18 and 19 depends on the next joined exon; both translations are shown separated by a slash. The transmembrane sequence is boxed. The putative SH3 domain-binding motifs (+XXPXXP and PXXPX+) in translations are underlined with solid line, and WW binding motifs (PPLP and PPR) with dashed line (P, proline; X, any amino acid; +, arginine or lysine). The putative NMD-targeting inframe stop codons are circled.