PITX3 wild-type and mutant proteins. A. Conservation of Pitx3 regions in different species. Amino acids that are identical in all or at least four proteins are highlighted in dark and light grey, correspondingly. Positions of mutations are shown in red. H.s- Homo sapiens, M.m.- Mus musculus, R.n.- Rattus Norvegicus, C.f.- Canis familiaris, D.r.- Danio rerio, X.l.- Xenopus laevis. B. Drawing of PITX3 wild-type and mutant proteins. The homeodomain is shown as green box, the OAR domain is shown as blue box and positions of mutations are indicated in red.