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Figure 5 | BMC Molecular Biology

Figure 5

From: XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions

Figure 5

Flexible response of XRCC1 to multiple DNA damage events. (A) Consecutive/Successive DNA lesions were introduced with a time interval of 2.5 min, starting 4 min after microirradiation of the first spot. One spot irradiated in close proximity to the nucleoli was not evaluated (arrowhead) (B) The recruitment kinetics of XRCC1 and PCNA at consecutively microirradiated sites were evaluated and plotted over time. Representative curves of one Hela cell are shown.

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BMC Molecular Biology

ISSN: 1471-2199

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