TY - JOUR AU - Gundelach, Holger AU - Braas, Daniel AU - Klempnauer, Karl-Heinz PY - 2007 DA - 2007/09/06 TI - The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication JO - BMC Molecular Biology SP - 75 VL - 8 IS - 1 AB - The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV). v-Myb is thought to exert its biological effects by deregulating the expression of specific target genes. We have recently demonstrated that the chicken Gas41 gene, whose promoter co-localizes with an origin of DNA replication, is a bona fide Myb target gene. Because of this finding we have asked whether other Myb-regulated genes are also associated with DNA replication origins. SN - 1471-2199 UR - https://doi.org/10.1186/1471-2199-8-75 DO - 10.1186/1471-2199-8-75 ID - Gundelach2007 ER -