Figure 1

Structure and chromosomal location of the human PPARδ gene. A. A physical map of the 85 kb human 6p21.31 region. The locations of exons are outlined with the previously known exons (denoted in upper row) and newly identified exons (denoted in lower row) indicated. The genomic positions of the new exons were deduced by comparing their sequences to that of the human PPARδ gene [GenBank: NM_006238]. The sequences of splice junctions and alternative 5'-ends related to these exons are outlined in Tables 1 and 2, respectively. B. A schematic representation of the PPARδ gene showing coding exons (white boxes), previously reported untranslated exons or part of exons (grey boxes), and herein identified untranslated exons (black boxes). The analysed and discussed variety of splicing among untranslated exons and alternative 5'-ends identified by Marathon 5'-RACE as described in "Methods" is shown below the gene (5'-UTRs: A-K).