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Table 1 Correlation between age, somatic expansion, ploidy and nuclearity in DM1 knock-in mice

From: Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

Age* 1 – 3 months 12 – 25 months
Somatic Expansion no yes
Ploidy 2n 4n 8n 2n 4n 8n
  54 ± 9% 45 ± 8% 2 ± 2% 45 ± 5% 43 ± 3% 13 ± 3%
Nuclearity 100% mononuclear 80% binuclear n.d. 100% mononuclear 80% binuclear 80% binuclear
  1. * n = 5 for 1–3 months-old mice and n = 8 for 12–25 months-old mice; n.d., not determined