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Table 1 Correlation between age, somatic expansion, ploidy and nuclearity in DM1 knock-in mice

From: Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

Age*

1 – 3 months

12 – 25 months

Somatic Expansion

no

yes

Ploidy

2n

4n

8n

2n

4n

8n

 

54 ± 9%

45 ± 8%

2 ± 2%

45 ± 5%

43 ± 3%

13 ± 3%

Nuclearity

100% mononuclear

80% binuclear

n.d.

100% mononuclear

80% binuclear

80% binuclear

  1. * n = 5 for 1–3 months-old mice and n = 8 for 12–25 months-old mice; n.d., not determined