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Table 6 Mutation types in phenotype- versus sequence-based screens

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

 

Phenotype-based screens

Sequence-based screen a

Mutation type

T-to-C

T-to-A

T-to-C

T-to-A

Missense

31

48

12

5

Make-sense

0

1

0

0

Nonsense

0

18

0

2

Synonymous

0

0

3

0

3' untranslated region

0

0

1

0

Intronic b

16

9

15

14

Total

47

76

31

21

  1. The number of T-to-C or T-to-A changes for each type of mutation is listed.
  2. a Only mutations detected in Sakuraba et al. [13] are included.
  3. b Intronic mutations include base replacement changes leading to aberrant splicing.