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Table 6 Mutation types in phenotype- versus sequence-based screens

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

  Phenotype-based screens Sequence-based screen a
Mutation type T-to-C T-to-A T-to-C T-to-A
Missense 31 48 12 5
Make-sense 0 1 0 0
Nonsense 0 18 0 2
Synonymous 0 0 3 0
3' untranslated region 0 0 1 0
Intronic b 16 9 15 14
Total 47 76 31 21
  1. The number of T-to-C or T-to-A changes for each type of mutation is listed.
  2. a Only mutations detected in Sakuraba et al. [13] are included.
  3. b Intronic mutations include base replacement changes leading to aberrant splicing.