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Table 5 Mutation types in ENU mutagenesis

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

 

Phenotype-based screens

Sequence-based screens

Mutation type

 

Present study

Germ cells a

ES cells

5' flanking

0

1

1

0

Exonic

    

   5' untranslated region

2

0

1

0

   Missense

175

44

45

18

   Make-sense

2

1

1

0

   Nonsense

46

3

4

0

   Synonymous

0

17

15

9

   3' untranslated region

0

1

2

0

Intronic b

52

63

8

4

Not specified

0

0

6

0

Total

277

130

83

31

  1. The number of occurrence for each type of mutation is listed.
  2. a Germline mutations detected in Sakuraba et al. [13] are not included.
  3. b Intronic mutations include base replacement changes leading to aberrant splicing.
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BMC Molecular Biology

ISSN: 1471-2199

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