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Table 5 Mutation types in ENU mutagenesis

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

  Phenotype-based screens Sequence-based screens
Mutation type   Present study Germ cells a ES cells
5' flanking 0 1 1 0
Exonic     
   5' untranslated region 2 0 1 0
   Missense 175 44 45 18
   Make-sense 2 1 1 0
   Nonsense 46 3 4 0
   Synonymous 0 17 15 9
   3' untranslated region 0 1 2 0
Intronic b 52 63 8 4
Not specified 0 0 6 0
Total 277 130 83 31
  1. The number of occurrence for each type of mutation is listed.
  2. a Germline mutations detected in Sakuraba et al. [13] are not included.
  3. b Intronic mutations include base replacement changes leading to aberrant splicing.
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BMC Molecular Biology

ISSN: 1471-2199

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