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Table 4 Reported number of base replacement changes in ENU mutagenesis

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

Base change

Phenotype- based screens

Sequence-based screens

From

To

  

Germ cells a

ES cells

T

C

47

(17.0)

12

(14.5)

3

(9.7)

 

A

76

(27.4)

15

(18.1)

4

(12.9)

 

G

13

(4.7)

1

(1.2)

3

(9.7)

C

T

21

(7.6)

5

(6.0)

9

(29.0)

 

A

16

(5.8)

4

(4.8)

1

(3.2)

 

G

2

(0.7)

0

(0.0)

2

(6.5)

A

T

24

(8.7)

6

(7.2)

0

(0.0)

 

C

7

(2.5)

1

(1.2)

0

(0.0)

 

G

41

(14.8)

18

(21.7)

5

(16.1)

G

T

10

(3.6)

12

(14.5)

1

(3.2)

 

C

0

(0.0)

1

(1.2)

0

(0.0)

 

A

20

(7.2)

8

(9.6)

3

(9.7)

Total

277

(100.0)

83

(100.0)

31

(100.0)

  1. Mutations are viewed as base changes on the nontranscribed strand. The relative proportion (in percentile) of each change is indicated in the parenthesis.
  2. a Germline mutations detected in Sakuraba et al. [13] are not included.
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BMC Molecular Biology

ISSN: 1471-2199

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