BMC Molecular Biology

Table 3 Amino acid-specific pattern of synonymous and nonsynonymous changes

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

	To
From	Ala	Arg	Asn	Asp	Cys	Gln	Glu	Gly	His	Ile	Leu	Lys	Met	Phe	Pro	Ser	Thr	Trp	Tyr	Val	X
Ala	41.9			5.3			2.6	0.0							1.3	7.6	17.6			23.7
Arg		35.0			6.7	5.9		10.1	5.0	1.7	4.7	8.2	1.8		0.8	7.1	0.6	7.2			5.3
Asn			25.5	19.0					2.1	8.5		15.4				19.0	2.1		8.5
Asp	2.2		16.4	27.3			16.7	20.2	1.2										7.0	9.0
Cys		25.6			21.0			4.1						5.3		18.3		2.0	12.4		11.2
Gln		23.2				19.9	0.0		10.3		10.3	8.4			2.6						25.3
Glu	2.7			11.3		1.4	21.5	24.2				19.7								10.8	8.4
Gly	1.4	11.0		9.9	4.3		9.6	41.3								9.9		2.0		8.4	2.2
His		19.5	7.1	0.0		15.3			25.9		8.7				2.2				21.3
Ile		0.6	14.4							26.6	2.7	2.7	3.7	5.6		3.4	25.1			15.1
Leu		3.4				8.4			5.8	3.5	36.1		4.6	7.0	21.0	5.1		0.6		0.8	3.7
Lys		22.4	10.4			2.5	22.4			3.9		19.8	6.1				2.5				10.0
Met		4.6								20.8	9.5	19.4					28.6			17.1
Phe					3.2					13.6	29.9			16.2		20.1			13.6	3.2
Pro	0.0	0.0				2.9			4.6		22.4				40.2	22.4	7.5
Ser	2.8	5.9	5.4		3.0			6.7		2.3	3.6			7.7	17.4	29.3	12.1	0.0	2.6		1.2
Thr	20.5	0.0	4.5							20.0		3.0	2.4		2.3	9.1	38.2
Trp		50.9			7.4			4.9			6.3					1.1					29.5
Tyr			16.7	4.0	14.8				24.7					6.6		1.6			19.8		11.9
Val	28.2			8.0			11.1	4.6		7.4	4.4		6.3	2.5						27.6
X		23.1			4.6	14.3	2.3	2.2			6.7	9.7				1.4		12.2	4.2		19.2

Expected proportions of synonymous versus nonsynonymous changes, conditional on a base replacement mutation within a given amino acid site, are indicated in percentile. Blanks correspond to changes that require multiple mutational steps. An X designates termination codons. Expected proportions of synonymous changes are indicated in italics.

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