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Table 3 Amino acid-specific pattern of synonymous and nonsynonymous changes

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

  To
From Ala Arg Asn Asp Cys Gln Glu Gly His Ile Leu Lys Met Phe Pro Ser Thr Trp Tyr Val X
Ala 41.9    5.3    2.6 0.0        1.3 7.6 17.6    23.7  
Arg   35.0    6.7 5.9   10.1 5.0 1.7 4.7 8.2 1.8   0.8 7.1 0.6 7.2    5.3
Asn    25.5 19.0      2.1 8.5   15.4     19.0 2.1   8.5   
Asp 2.2   16.4 27.3    16.7 20.2 1.2           7.0 9.0  
Cys   25.6    21.0    4.1       5.3   18.3   2.0 12.4   11.2
Gln   23.2     19.9 0.0   10.3   10.3 8.4    2.6       25.3
Glu 2.7    11.3   1.4 21.5 24.2     19.7         10.8 8.4
Gly 1.4 11.0   9.9 4.3   9.6 41.3         9.9   2.0   8.4 2.2
His   19.5 7.1 0.0   15.3    25.9   8.7     2.2     21.3   
Ile   0.6 14.4        26.6 2.7 2.7 3.7 5.6   3.4 25.1    15.1  
Leu   3.4     8.4    5.8 3.5 36.1   4.6 7.0 21.0 5.1   0.6   0.8 3.7
Lys   22.4 10.4    2.5 22.4    3.9   19.8 6.1     2.5     10.0
Met   4.6         20.8 9.5 19.4      28.6    17.1  
Phe      3.2      13.6 29.9    16.2   20.1    13.6 3.2  
Pro 0.0 0.0     2.9    4.6   22.4     40.2 22.4 7.5     
Ser 2.8 5.9 5.4   3.0    6.7   2.3 3.6    7.7 17.4 29.3 12.1 0.0 2.6   1.2
Thr 20.5 0.0 4.5        20.0   3.0 2.4   2.3 9.1 38.2     
Trp   50.9    7.4    4.9    6.3      1.1      29.5
Tyr    16.7 4.0 14.8     24.7      6.6   1.6    19.8   11.9
Val 28.2    8.0    11.1 4.6   7.4 4.4   6.3 2.5       27.6  
X   23.1    4.6 14.3 2.3 2.2    6.7 9.7     1.4   12.2 4.2   19.2
  1. Expected proportions of synonymous versus nonsynonymous changes, conditional on a base replacement mutation within a given amino acid site, are indicated in percentile. Blanks correspond to changes that require multiple mutational steps. An X designates termination codons. Expected proportions of synonymous changes are indicated in italics.